Next Article in Journal
Dietary Supplements for Male Infertility: A Critical Evaluation of Their Composition
Previous Article in Journal
Promising Effect of a New Ketogenic Diet Regimen in Patients with Advanced Cancer
Previous Article in Special Issue
Dietary Potassium Attenuates the Effects of Dietary Sodium on Vascular Function in Salt-Resistant Adults
Open AccessArticle

The Effects of Two Intervention Strategies to Reduce the Intake of Salt and the Sodium-To-Potassium Ratio on Cardiovascular Risk Factors. A 4-Month Randomised Controlled Study among Healthy Families

1
Center for Clinical Research and Prevention, Bispebjerg and Frederiksberg Hospital, 2000 Frederiksberg, Denmark
2
Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
3
National Food Institute, Technical University of Denmark, 2800 Kgs. Lyngby, Denmark
4
Department of Clinical Biochemistry, Rigshospitalet, 2100 Copenhagen, Denmark
5
Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, 2100 Copenhagen, Denmark
6
Department of Clinical Biochemistry, Amager and Hvidovre Hospital, 2650 Hvidovre, Denmark
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1467; https://doi.org/10.3390/nu12051467
Received: 31 March 2020 / Revised: 12 May 2020 / Accepted: 13 May 2020 / Published: 19 May 2020
(This article belongs to the Special Issue Dietary Potassium and Human Health)
The aim was to examine the effects of two different salt reduction strategies on selected cardiovascular risk factors. The study was a four-month cluster randomised controlled study. Eighty-nine healthy Danish families (309 individuals) were randomly assigned to either (A) gradually salt-reduced bread, (B) gradually salt-reduced bread and dietary counselling to further reduce salt intake and increase potassium intake or (C) standard bread (control). The effect was assessed using linear mixed models. Intention to treat analyses comparing changes in the three groups showed a significant reduction in body fat percent (−1.31% (−2.40; −0.23)) and a borderline significant reduction in total plasma cholesterol (−0.25 mmol/L (−0.51; 0.01) and plasma renin (−0.19 pmol/L (−0.39; 0.00) in group A compared to the control group. Adjusted complete case analyses showed a significant reduction in total plasma cholesterol (−0.29 mmol/L (−0.50; −0.08), plasma LDL cholesterol (−0.08 mmol/L (−0.15; −0.00)), plasma renin (−0.23 pmol/L (−0.41; −0.05)), plasma adrenaline (−0.03 nmol/L (−0.06; −0.01)) and body fat percent (−1.53% (−2.51; −0.54)) in group A compared to the control group. No significant changes were found in group B compared to the control group. In conclusion, receiving sodium reduce bread was associated with beneficial changes in cardiovascular risk factors. No adverse effects were observed. View Full-Text
Keywords: salt reduction; potassium; families; real life clinical trial; bread reformulation; cardiovascular risk factors salt reduction; potassium; families; real life clinical trial; bread reformulation; cardiovascular risk factors
Show Figures

Figure 1

MDPI and ACS Style

Toft, U.; Riis, N.L.; Lassen, A.D.; Trolle, E.; Andreasen, A.H.; Frederiksen, A.K.S.; Joergensen, N.R.; Munk, J.K.; Bjoernsbo, K.S. The Effects of Two Intervention Strategies to Reduce the Intake of Salt and the Sodium-To-Potassium Ratio on Cardiovascular Risk Factors. A 4-Month Randomised Controlled Study among Healthy Families. Nutrients 2020, 12, 1467.

AMA Style

Toft U, Riis NL, Lassen AD, Trolle E, Andreasen AH, Frederiksen AKS, Joergensen NR, Munk JK, Bjoernsbo KS. The Effects of Two Intervention Strategies to Reduce the Intake of Salt and the Sodium-To-Potassium Ratio on Cardiovascular Risk Factors. A 4-Month Randomised Controlled Study among Healthy Families. Nutrients. 2020; 12(5):1467.

Chicago/Turabian Style

Toft, Ulla; Riis, Nanna L.; Lassen, Anne D.; Trolle, Ellen; Andreasen, Anne H.; Frederiksen, Amalie K.S.; Joergensen, Niklas R.; Munk, Jens K.; Bjoernsbo, Kirsten S. 2020. "The Effects of Two Intervention Strategies to Reduce the Intake of Salt and the Sodium-To-Potassium Ratio on Cardiovascular Risk Factors. A 4-Month Randomised Controlled Study among Healthy Families" Nutrients 12, no. 5: 1467.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop