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Article

Effects of Prunus cerasus L. Seeds and Juice on Liver Steatosis in an Animal Model of Diet-Induced Obesity

1
School of Pharmacy, University of Camerino, 62032 Camerino, Italy
2
Department of Medicine, University of Leipzig, 04103 Leipzig, Germany
3
School of Biosciences and Veterinary Medicine, University of Camerino, 62032 Camerino, Italy
4
Department of Molecular Medicine, University “Sapienza”, 00185 Rome, Italy
*
Authors to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(5), 1308; https://doi.org/10.3390/nu12051308
Received: 21 March 2020 / Revised: 24 April 2020 / Accepted: 26 April 2020 / Published: 4 May 2020
(This article belongs to the Section Phytochemicals and Human Health)
The accumulation of adipose tissue increases the risk of several diseases. The fruits-intake, containing phytochemicals, is inversely correlated with their development. This study evaluated the effects of anthocyanin-rich tart cherries in diet-induced obese (DIO) rats. DIO rats were exposed to a high-fat diet with the supplementation of tart cherry seeds powder (DS) and seed powder plus juice (DJS). After 17 weeks, the DIO rats showed an increase of body weight, glycaemia, insulin, and systolic blood pressure. In the DS and DJS groups, there was a decrease of systolic blood pressure, glycaemia, triglycerides, and thiobarbituric reactive substances in the serum. In the DJS rats, computed tomography revealed a decrease in the spleen-to-liver attenuation ratio. Indeed, sections of the DIO rats presented hepatic injury characterized by steatosis, which was lower in the supplemented groups. In the liver of the DIO compared with rats fed with a standard diet (CHOW), a down-regulation of the GRP94 protein expression and a reduction of LC3- II/LC3-I ratio were found, indicating endoplasmic reticulum stress and impaired autophagy flux. Interestingly, tart cherry supplementation enhanced both unfolded protein response (UPR) and autophagy. This study suggests that tart cherry supplementation, although it did not reduce body weight in the DIO rats, prevented its related risk factors and liver steatosis. View Full-Text
Keywords: diet-induced obese rats; liver; obesity; tart cherry; anthocyanins diet-induced obese rats; liver; obesity; tart cherry; anthocyanins
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MDPI and ACS Style

Martinelli, I.; Micioni Di Bonaventura, M.V.; Moruzzi, M.; Amantini, C.; Maggi, F.; Gabrielli, M.G.; Fruganti, A.; Marchegiani, A.; Dini, F.; Marini, C.; Polidori, C.; Lupidi, G.; Amenta, F.; Tayebati, S.K.; Cifani, C.; Tomassoni, D. Effects of Prunus cerasus L. Seeds and Juice on Liver Steatosis in an Animal Model of Diet-Induced Obesity. Nutrients 2020, 12, 1308. https://doi.org/10.3390/nu12051308

AMA Style

Martinelli I, Micioni Di Bonaventura MV, Moruzzi M, Amantini C, Maggi F, Gabrielli MG, Fruganti A, Marchegiani A, Dini F, Marini C, Polidori C, Lupidi G, Amenta F, Tayebati SK, Cifani C, Tomassoni D. Effects of Prunus cerasus L. Seeds and Juice on Liver Steatosis in an Animal Model of Diet-Induced Obesity. Nutrients. 2020; 12(5):1308. https://doi.org/10.3390/nu12051308

Chicago/Turabian Style

Martinelli, Ilenia, Maria V. Micioni Di Bonaventura, Michele Moruzzi, Consuelo Amantini, Federica Maggi, Maria G. Gabrielli, Alessandro Fruganti, Andrea Marchegiani, Fabrizio Dini, Carlotta Marini, Carlo Polidori, Giulio Lupidi, Francesco Amenta, Seyed K. Tayebati, Carlo Cifani, and Daniele Tomassoni. 2020. "Effects of Prunus cerasus L. Seeds and Juice on Liver Steatosis in an Animal Model of Diet-Induced Obesity" Nutrients 12, no. 5: 1308. https://doi.org/10.3390/nu12051308

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