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Open AccessFeature PaperArticle

Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise

1
Secció de Fisiologia, Departament de Bioquímica i Fisiologia, Facultat de Farmàcia i Ciències de l’Alimentació, Universitat de Barcelona (UB), 08028 Barcelona, Spain
2
Institut de Recerca en Nutrició i Seguretat Alimentària (INSA-UB), UB, 08921 Santa Coloma de Gramenet, Spain
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1291; https://doi.org/10.3390/nu12051291
Received: 27 March 2020 / Revised: 22 April 2020 / Accepted: 27 April 2020 / Published: 1 May 2020
(This article belongs to the Special Issue Immune Function and Nutrient Supplementation)
Intensive training and exhausting exercise can disrupt innate and acquired immunity. The flavanone hesperidin has shown immunomodulatory properties in physiological and some pathological conditions, and positive effects on exercise-induced oxidative stress. Nevertheless, it remains uncertain whether it also prevents exhausting exercise-induced immune alterations. The aim of this study was to establish the effect of oral hesperidin supplementation on the systemic immune system in rats following an intensive training and exhausting exercise. For this purpose, female Wistar rats were randomized into an intensive training group or a sedentary group. Intensive training was induced by running in a treadmill 5 days per week (including two exhausting tests) for five weeks. Throughout the training period, 200 mg/kg of hesperidin or vehicle was administered by oral gavage three times per week. At the end, blood, thymus, spleen and macrophages were collected before, immediately after and 24 h after an additional final exhaustion test. Hesperidin supplementation enhanced natural killer cell cytotoxicity and the proportion of phagocytic monocytes, attenuated the secretion of cytokines by stimulated macrophages, prevented the leukocytosis induced by exhaustion and increased the proportion of T helper cells in the thymus, blood and spleen. These results suggest that hesperidin can prevent exhausting exercise-induced immune alterations. View Full-Text
Keywords: blood; cytokines; exercise; exhaustion; lymphocytes; macrophages; NK cells; phagocytosis; spleen; thymus blood; cytokines; exercise; exhaustion; lymphocytes; macrophages; NK cells; phagocytosis; spleen; thymus
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MDPI and ACS Style

Ruiz-Iglesias, P.; Estruel-Amades, S.; Camps-Bossacoma, M.; Massot-Cladera, M.; Franch, À.; Pérez-Cano, F.J.; Castell, M. Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise. Nutrients 2020, 12, 1291. https://doi.org/10.3390/nu12051291

AMA Style

Ruiz-Iglesias P, Estruel-Amades S, Camps-Bossacoma M, Massot-Cladera M, Franch À, Pérez-Cano FJ, Castell M. Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise. Nutrients. 2020; 12(5):1291. https://doi.org/10.3390/nu12051291

Chicago/Turabian Style

Ruiz-Iglesias, Patricia; Estruel-Amades, Sheila; Camps-Bossacoma, Mariona; Massot-Cladera, Malén; Franch, Àngels; Pérez-Cano, Francisco J.; Castell, Margarida. 2020. "Influence of Hesperidin on Systemic Immunity of Rats Following an Intensive Training and Exhausting Exercise" Nutrients 12, no. 5: 1291. https://doi.org/10.3390/nu12051291

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