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Vitamin D’s Effect on Immune Function

Clinical and Experimental Endocrinology (CEE), KU Leuven, Campus Gasthuisberg O&N1, Herestraat 49, box 902, 3000 Leuven, Belgium
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Nutrients 2020, 12(5), 1248; https://doi.org/10.3390/nu12051248
Received: 5 April 2020 / Revised: 24 April 2020 / Accepted: 26 April 2020 / Published: 28 April 2020
(This article belongs to the Special Issue Vitamin D on Immune Function)
Ever since its discovery by Windhaus, the importance of the active metabolite of vitamin D (1,25-dihydroxyvitamin D3; 1,25-(OH)2D3) has been ever expanding. In this review, the attention is shifted towards the importance of the extra-skeletal effects of vitamin D, with special emphasis on the immune system. The first hint of the significant role of vitamin D on the immune system was made by the discovery of the presence of the vitamin D receptor on almost all cells of the immune system. In vitro, the overwhelming effect of supra-physiological doses of vitamin D on the individual components of the immune system is very clear. Despite these promising pre-clinical results, the translation of the in vitro observations to solid clinical effects has mostly failed. Nevertheless, the evidence of a link between vitamin D deficiency and adverse outcomes is overwhelming and clearly points towards avoidance of vitamin D deficiency especially in early life. View Full-Text
Keywords: vitamin D; 1,25-(OH)2D3; immune system; autoimmune disease; infectious disease; type 1 diabetes; multiple sclerosis; rheumatoid arthritis vitamin D; 1,25-(OH)2D3; immune system; autoimmune disease; infectious disease; type 1 diabetes; multiple sclerosis; rheumatoid arthritis
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Martens, P.-J.; Gysemans, C.; Verstuyf, A.; Mathieu, C. Vitamin D’s Effect on Immune Function. Nutrients 2020, 12, 1248.

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