Next Article in Journal
Vitamin D’s Effect on Immune Function
Next Article in Special Issue
Variations in Magnesium Concentration Are Associated with Increased Mortality: Study in an Unselected Population of Hospitalized Patients
Previous Article in Journal
The Role of CT-Quantified Body Composition on Longitudinal Health-Related Quality of Life in Colorectal Cancer Patients: The Colocare Study
Open AccessArticle

Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial

1
Public Health Nutrition, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106, USA
2
Department of Nutrition and Food Studies, George Mason University, MS1F7, 4400 University Drive, Fairfax, VA 22030, USA
3
Think Healthy Group, Inc., 1301 20th Street NW, Washington, DC 20036, USA
4
Center for Magnesium Education & Research, 13-1255 Malama Street, Pahoa, HI 96778, USA
5
Department of Nutrition Science, Purdue University, 700 West State Street, West Lafayette, IN 47907, USA
6
Department of Applied Health Science, School of Public Health, Indiana University Bloomington, Bloomington, IN 47405, USA
7
Weaver and Associates Consulting, LLC, West Lafayette, IN 47906, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1245; https://doi.org/10.3390/nu12051245
Received: 24 March 2020 / Revised: 9 April 2020 / Accepted: 22 April 2020 / Published: 28 April 2020
(This article belongs to the Special Issue Magnesium in Human Health and Disease)
Oral supplementation may improve the dietary intake of magnesium, which has been identified as a shortfall nutrient. We conducted a pilot study to evaluate appropriate methods for assessing responses to the ingestion of oral magnesium supplements, including ionized magnesium in whole blood (iMg2+) concentration, serum total magnesium concentration, and total urinary magnesium content. In a single-blinded crossover study, 17 healthy adults were randomly assigned to consume 300 mg of magnesium from MgCl2 (ReMag®, a picosized magnesium formulation) or placebo, while having a low-magnesium breakfast. Blood and urine samples were obtained for the measurement of iMg2+, serum total magnesium, and total urine magnesium, during 24 h following the magnesium supplement or placebo dosing. Bioavailability was assessed using area-under-the-curve (AUC) as well as maximum (Cmax) and time-to-maximum (Tmax) concentration. Depending on normality, data were expressed as the mean ± standard deviation or median (range), and differences between responses to MgCl2 or placebo were measured using the paired t-test or Wilcoxon signed-rank test. Following MgCl2 administration versus placebo administration, we observed significantly greater increases in iMg2+ concentrations (AUC = 1.51 ± 0.96 vs. 0.84 ± 0.82 mg/dL•24h; Cmax = 1.38 ± 0.13 vs. 1.32 ± 0.07 mg/dL, respectively; both p < 0.05) but not in serum total magnesium (AUC = 27.00 [0, 172.93] vs. 14.55 [0, 91.18] mg/dL•24h; Cmax = 2.38 [1.97, 4.01] vs. 2.24 [1.98, 4.31] mg/dL) or in urinary magnesium (AUC = 201.74 ± 161.63 vs. 139.30 ± 92.84 mg•24h; Cmax = 26.12 [12.91, 88.63] vs. 24.38 [13.51, 81.51] mg/dL; p > 0.05). Whole blood iMg2+ may be a more sensitive measure of acute oral intake of magnesium compared to serum and urinary magnesium and may be preferred for assessing supplement bioavailability. View Full-Text
Keywords: magnesium; iMg; biomarkers; nutritional status; diet magnesium; iMg; biomarkers; nutritional status; diet
Show Figures

Figure 1

MDPI and ACS Style

Zhan, J.; Wallace, T.C.; Butts, S.J.; Cao, S.; Ansu, V.; Spence, L.A.; Weaver, C.M.; Gletsu-Miller, N. Circulating Ionized Magnesium as a Measure of Supplement Bioavailability: Results from a Pilot Study for Randomized Clinical Trial. Nutrients 2020, 12, 1245.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop