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Open AccessArticle

The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial

School of Nutrition, University of Vienna, 1090 Vienna, Austria
Health and Nutrition Specialist, Health and Nutrition Department for UNICEF Regional Office for Europe and Central Asia, Almaty 050000, Kazakhstan
School of Nutrition and Dietetics, Tehran University of Medical Science, Tehran 14155/6117, Iran
Nutrition Department of the Ministry of health and Medical Education, Tehran 1467664961, Iran
Deputy Director of Family Health Department of the Ministry of Health and Medical Education, Tehran 1467664961, Iran
Ramin Heshmat, Tehran University of Medical Sciences, Tehran 141675395, Iran
Author to whom correspondence should be addressed.
Nutrients 2020, 12(5), 1213;
Received: 12 April 2020 / Revised: 22 April 2020 / Accepted: 22 April 2020 / Published: 25 April 2020
(This article belongs to the Special Issue The Role of Vitamin D in Chronic Diseases)
Background: Deficiency of vitamin D, an anti-inflammatory micronutrient with some favorable effects on lipid profiles, has been found to be highly prevalent in adolescents. We aimed to investigate the effect of a school-based vitamin D supplementation regimen on the correction of vitamin D deficiency as well as lipid and inflammatory profiles of healthy adolescent boys. Methods: In this randomized single-blind placebo-controlled trial, seventy-one healthy adolescent boys (age 17 years old) were recruited from one high school in Tehran, Iran, and randomly assigned to two groups. The supplement group received vitamin D pearls at a dose of 50,000 IU monthly for 6 months, this dose is indeed defined by the Ministry of Health in Iran for a potential national school-based vitamin D supplementation program. The other group was given placebo pearls for the same duration. Before and after the treatment, the serum levels of 25-hydroxy vitamin D (25(OH) D), parathyroid hormone (PTH), retinol, lead (Pb), the lipid profile and the inflammatory biomarkers were measured and compared. Results: Between-groups statistical analysis showed that a dose (50,000 IU/month) vitamin D significantly increased the serum levels of 25-hydroxyvitamin D (25 (OH) D) (p < 0.001) and decreased serum levels of PTH (p = 0.003). No significant change was observed in serum levels of retinol and Pb. Between-group analysis revealed that the serum levels of TG (P = 0.001) decreased while an increase in serum levels of HDL (p = 0.021) was observed (p < 0.05). Both the within- and between-group analysis showed that serum tumor necrosis factor receptor 2 (TNFR2) concentration declined while serum interleukin-10 (IL-10) increased in response to vitamin D supplementation (p < 0.05). Conclusion: A supplementation regimen of (50,000 IU/month) vitamin D in a context with high rates of vitamin deficiency has shown positive impacts on the serum vitamin D, lipid profile and inflammatory biomarkers in healthy adolescent boys. View Full-Text
Keywords: vitamin D supplementation; adolescent; inflammation; lipid profile; PTH vitamin D supplementation; adolescent; inflammation; lipid profile; PTH
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Yarparvar, A.; Elmadfa, I.; Djazayery, A.; Abdollahi, Z.; Salehi, F.; Heshmat, R. The Effects of Vitamin D Supplementation on Lipid and Inflammatory Profile of Healthy Adolescent Boys: A Randomized Controlled Trial. Nutrients 2020, 12, 1213.

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