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A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor

1
Department of Obstetrics & Gynecology, Emek Medical Center, Afula 1834111, Israel
2
Department of Obstetrics & Gynecology, Baruch Padeh Medical Center Poriya, Tiberias 1410000, Israel
3
Faculty of Medicine in Galilee, Bar-Ilan University, Safed 1310000, Israel
4
Microbiology Laboratory, Emek Medical Center, Afula 1834111, Israel
5
Rappaport Faculty of Medicine, Technion, Haifa 3200003, Israel
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(4), 1141; https://doi.org/10.3390/nu12041141
Received: 5 March 2020 / Revised: 15 April 2020 / Accepted: 16 April 2020 / Published: 19 April 2020
(This article belongs to the Section Clinical Nutrition)
Lactobacilli administration has been suggested for the treatment and prevention of bacterial vaginosis, which increases the risk for preterm birth. We aimed to evaluate the vaginal colonization of lactobacilli orally administered to pregnant women at risk for preterm birth. We performed a randomized and controlled crossover study between January 2016 and May 2017. Forty pregnant women at high risk for preterm birth with normal vaginal flora (Nugent score ≤ 3) were randomized to either receive two oral capsules/day each containing 5 × 109 Lactobacilli (L.) rhamnosus GR-1 and L. reuteri RC-14 (n = 20) or no treatment (n = 20) for 2 months. Treatments were then crossed over for an additional two months. A vaginal examination and swabbing were performed for assessment of bacterial vaginosis at baseline and every month until study completion. At the same time points, vaginal samples were cultured and subjected to matrix-assisted-laser-desorption/ionization-time-of-flight-mass-spectrometry (MALDI TOF-MS) for the detection of the specific bacterial strains contained in the capsules. The primary endpoint was the presence of the administered lactobacilli strains in the vagina during the first two months of follow-up. Thirty-eight women completed the study. During the first two months of treatment, L. rhamnosus GR-1 was detected in one (5%) woman on the probiotic treatment and 2 (11%) women receiving no treatment (p = 0.6). L. rhamnosus GR-1 was detected in vaginal samples of 4 (11%) women during probiotic treatment (of both groups) and L. reuteri RC-14 was not detected in any samples. The rest of the endpoints were not different between the groups. Altogether, vaginal colonization of lactobacilli following oral administration is low during pregnancy. View Full-Text
Keywords: pregnancy; probiotics; lactobacilli; bacterial vaginosis; preterm delivery; abnormal vaginal flora pregnancy; probiotics; lactobacilli; bacterial vaginosis; preterm delivery; abnormal vaginal flora
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MDPI and ACS Style

Yefet, E.; Colodner, R.; Strauss, M.; Gam Ze Letova, Y.; Nachum, Z. A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor. Nutrients 2020, 12, 1141. https://doi.org/10.3390/nu12041141

AMA Style

Yefet E, Colodner R, Strauss M, Gam Ze Letova Y, Nachum Z. A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor. Nutrients. 2020; 12(4):1141. https://doi.org/10.3390/nu12041141

Chicago/Turabian Style

Yefet, Enav, Raul Colodner, Merav Strauss, Yifat Gam Ze Letova, and Zohar Nachum. 2020. "A Randomized Controlled Open Label Crossover Trial to Study Vaginal Colonization of Orally Administered Lactobacillus Reuteri RC-14 and Rhamnosus GR-1 in Pregnant Women at High Risk for Preterm Labor" Nutrients 12, no. 4: 1141. https://doi.org/10.3390/nu12041141

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