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Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues

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University of Lille, Inserm, CHU Lille, Institut Pasteur de Lille, U1167 - RID-AGE - Facteurs de risque et déterminants moléculaires des maladies liées au vieillissement, F-59000 Lille, France
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University of Lille, CNRS UMR9017, Inserm U1019, CHRU Lille, Institut Pasteur de Lille, CIIL - Center for Infection and Immunity of Lille, 59000 Lille, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(3), 827; https://doi.org/10.3390/nu12030827
Received: 19 February 2020 / Revised: 11 March 2020 / Accepted: 18 March 2020 / Published: 20 March 2020
(This article belongs to the Section Nutrition and Public Health)
Unhealthy lifestyle choices, such as bad eating behaviors and cigarette smoking, have major detrimental impacts on health. However, the inter-relations between obesity and smoking are still not fully understood. We thus developed an experimental model of high-fat diet-fed obese C57BL/6 male mice chronically exposed to cigarette smoke. Our study evaluated for the first time the resulting effects of the combined exposure to unhealthy diet and cigarette smoke on several metabolic, pulmonary, intestinal, and cardiac parameters. We showed that the chronic exposure to cigarette smoke modified the pattern of body fat distribution in favor of the visceral depots in obese mice, impaired the respiratory function, triggered pulmonary inflammation and emphysema, and was associated with gut microbiota dysbiosis, cardiac hypertrophy and myocardial fibrosis. View Full-Text
Keywords: unhealthy lifestyle; cigarette; obesity; lung; heart; metabolism; gut; microbiota unhealthy lifestyle; cigarette; obesity; lung; heart; metabolism; gut; microbiota
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Dubois-Deruy, E.; Rémy, G.; Alard, J.; Kervoaze, G.; Chwastyniak, M.; Baron, M.; Beury, D.; Siegwald, L.; Caboche, S.; Hot, D.; Gosset, P.; Grangette, C.; Pinet, F.; Wolowczuk, I.; Pichavant, M. Modelling the Impact of Chronic Cigarette Smoke Exposure in Obese Mice: Metabolic, Pulmonary, Intestinal, and Cardiac Issues. Nutrients 2020, 12, 827.

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