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Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study

Department of Medicine, Faculty of Medicine and Life Sciences, University of Barcelona, Barcelona, Spain. Institut d’Investigacions Biomèdiques August Pi I Sunyer (IDIBAPS), 08036 Barcelona, Spain
Centro de Investigación Biomédica en Red Fisiopatología de la Obesidad y la Nutrición (CIBEROBN), Instituto de Salud Carlos III, 28029 Madrid, Spain
Universitat Rovira i Virgili, Departament de Bioquímica i Biotecnologia, Unitat de Nutrició, 43204 Reus, Spain
University Hospital of Sant Joan de Reus, Nutrition Unit, 43201 Reus, Spain
Institut d’Investigació Sanitària Pere Virgili (IISPV), 43201 Reus, Spain
Institute of Biomedicine (IBIOMED), University of León, 24071 León, Spain
CIBER de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
University of Navarra, Department of Preventive Medicine and Public Health, Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain
Servicio Navarro de Salud-Osasunbidea-Instituto de Investigación Sanitaria de Navarra (IdiSNA), 31008 Pamplona, Spain
Department of Preventive Medicine, University of Valencia, 46010 Valencia, Spain
Cardiovascular Risk and Nutrition Research group, Institut Hospital del Mar de Investigaciones Médicas (IMIM), 08007 Barcelona, Spain
Health Research Institute of the Balearic Islands (IdISBa), University Hospital Son Espases (Research Unit), 07120 Palma de Mallorca, Spain
Miguel Hernandez University, ISABIAL-FISABIO, 03010 Alicante, Spain
Bioaraba Health Research Institute; Osakidetza Basque Health Service, Araba University Hospital; University of the Basque Country UPV/EHU, 01009 Vitoria-Gasteiz, Spain
Department of Nursing. University of Málaga, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
Department of Nutrition, Food Sciences, and Physiology, Center for Nutrition Research, University of Navarra, 31008 Pamplona, Spain
Precision Nutrition Program, IMDEA Food, CEI UAM + CSIC, 28049 Madrid, Spain
Research Institute of Biomedical and Health Sciences (IUIBS), University of Las Palmas de Gran Canaria & Centro Hospitalario Universitario Insular Materno Infantil (CHUIMI), Canarian Health Service, 35016 Las Palmas de Gran Canaria, Spain
Virgen de la Victoria Hospital, Department of Endocrinology, Instituto de Investigación Biomédica de Málaga (IBIMA). University of Málaga, 29010 Málaga, Spain
Department of Family Medicine, Research Unit, Distrito Sanitario Atención Primaria Sevilla, 41010 Sevilla, Spain
Lipids and Vascular Risk Unit, Internal Medicine, Hospital Universitario de Bellvitge, IDIBELL, Hospitalet de Llobregat, 08908 Barcelona, Spain
Research Group on Community Nutrition & Oxidative Stress, University of Balearic Islands, 07122 Palma de Mallorca, Spain
Department of Internal Medicine, Maimonides Biomedical Research Institute of Cordoba (IMIBIC), Reina Sofia University Hospital, University of Cordoba, 14004 Cordoba, Spain
Department of Preventive Medicine and Public Health, University of Granada, 18016 Granada, Spain
Division of Preventive Medicine, Faculty of Medicine, University of Jaén, 23071 Jaén, Spain
Department of Endocrinology and Nutrition, Instituto de Investigación Sanitaria Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain
CIBER Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
Department of Endocrinology, Institut d’Investigacions Biomédiques August Pi Sunyer (IDIBAPS), Hospital Clinic, University of Barcelona, 08036 Barcelona, Spain
Department of Endocrinology and Nutrition, Hospital Fundación Jimenez Díaz, Instituto de Investigaciones Biomédicas IISFJD. University Autonoma, 28040 Madrid, Spain
Lipid Clinic, Department of Endocrinology and Nutrition, Institut d’Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Hospital Clínic, 08036 Barcelona, Spain
Unidad de Gestión Clínica de Endocrinología y Nutrición del Hospital Virgen de la Victoria, Instituto de Investigación Biomédica de Málaga (IBIMA), 29010 Málaga, Spain
Centro de Salud Raval, 03203 Alicante, Spain
Department of Nutrition, Food Science and Gastronomy, XaRTA, INSA, School of Pharmacy and Food Sciences, University of Barcelona, 08028 Barcelona, Spain
Department of Internal Medicine, Hospital Clinic de Barcelona, 08036 Barcelona, Spain
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(3), 689;
Received: 7 February 2020 / Revised: 28 February 2020 / Accepted: 29 February 2020 / Published: 4 March 2020
(This article belongs to the Special Issue Dietary Polyphenols and Human Health)
Dietary polyphenol intake is associated with improvement of metabolic disturbances. The aims of the present study are to describe dietary polyphenol intake in a population with metabolic syndrome (MetS) and to examine the association between polyphenol intake and the components of MetS. This cross-sectional analysis involved 6633 men and women included in the PREDIMED (PREvención con DIeta MEDiterranea-Plus) study. The polyphenol content of foods was estimated from the Phenol-Explorer 3.6 database. The mean of total polyphenol intake was 846 ± 318 mg/day. Except for stilbenes, women had higher polyphenol intake than men. Total polyphenol intake was higher in older participants (>70 years of age) compared to their younger counterparts. Participants with body mass index (BMI) >35 kg/m2 reported lower total polyphenol, flavonoid, and stilbene intake than those with lower BMI. Total polyphenol intake was not associated with a better profile concerning MetS components, except for high-density lipoprotein cholesterol (HDL-c), although stilbenes, lignans, and other polyphenols showed an inverse association with blood pressure, fasting plasma glucose, and triglycerides. A direct association with HDL-c was found for all subclasses except lignans and phenolic acids. To conclude, in participants with MetS, higher intake of several polyphenol subclasses was associated with a better profile of MetS components, especially HDL-c. View Full-Text
Keywords: polyphenols; metabolic syndrome; Mediterranean diet; glignans; stilbenes; HDL-cholesterol polyphenols; metabolic syndrome; Mediterranean diet; glignans; stilbenes; HDL-cholesterol
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MDPI and ACS Style

Castro-Barquero, S.; Tresserra-Rimbau, A.; Vitelli-Storelli, F.; Doménech, M.; Salas-Salvadó, J.; Martín-Sánchez, V.; Rubín-García, M.; Buil-Cosiales, P.; Corella, D.; Fitó, M.; Romaguera, D.; Vioque, J.; Alonso-Gómez, Á.M.; Wärnberg, J.; Martínez, J.A.; Serra-Majem, L.; Tinahones, F.J.; Lapetra, J.; Pintó, X.; Tur, J.A.; Garcia-Rios, A.; García-Molina, L.; Delgado-Rodriguez, M.; Matía-Martín, P.; Daimiel, L.; Vidal, J.; Vázquez, C.; Cofán, M.; Romanos-Nanclares, A.; Becerra-Tomas, N.; Barragan, R.; Castañer, O.; Konieczna, J.; González-Palacios, S.; Sorto-Sánchez, C.; Pérez-López, J.; Zulet, M.A.; Bautista-Castaño, I.; Casas, R.; Gómez-Perez, A.M.; Santos-Lozano, J.M.; Rodríguez-Sanchez, M.Á.; Julibert, A.; Martín-Calvo, N.; Hernández-Alonso, P.; Sorlí, J.V; Sanllorente, A.; Galmés-Panadés, A.M.; Cases-Pérez, E.; Goicolea-Güemez, L.; Ruiz-Canela, M.; Babio, N.; Hernáez, Á.; Lamuela-Raventós, R.M.; Estruch, R. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study. Nutrients 2020, 12, 689.

AMA Style

Castro-Barquero S, Tresserra-Rimbau A, Vitelli-Storelli F, Doménech M, Salas-Salvadó J, Martín-Sánchez V, Rubín-García M, Buil-Cosiales P, Corella D, Fitó M, Romaguera D, Vioque J, Alonso-Gómez ÁM, Wärnberg J, Martínez JA, Serra-Majem L, Tinahones FJ, Lapetra J, Pintó X, Tur JA, Garcia-Rios A, García-Molina L, Delgado-Rodriguez M, Matía-Martín P, Daimiel L, Vidal J, Vázquez C, Cofán M, Romanos-Nanclares A, Becerra-Tomas N, Barragan R, Castañer O, Konieczna J, González-Palacios S, Sorto-Sánchez C, Pérez-López J, Zulet MA, Bautista-Castaño I, Casas R, Gómez-Perez AM, Santos-Lozano JM, Rodríguez-Sanchez MÁ, Julibert A, Martín-Calvo N, Hernández-Alonso P, Sorlí JV, Sanllorente A, Galmés-Panadés AM, Cases-Pérez E, Goicolea-Güemez L, Ruiz-Canela M, Babio N, Hernáez Á, Lamuela-Raventós RM, Estruch R. Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study. Nutrients. 2020; 12(3):689.

Chicago/Turabian Style

Castro-Barquero, Sara; Tresserra-Rimbau, Anna; Vitelli-Storelli, Facundo; Doménech, Mónica; Salas-Salvadó, Jordi; Martín-Sánchez, Vicente; Rubín-García, María; Buil-Cosiales, Pilar; Corella, Dolores; Fitó, Montserrat; Romaguera, Dora; Vioque, Jesús; Alonso-Gómez, Ángel M.; Wärnberg, Julia; Martínez, José A.; Serra-Majem, Luís; Tinahones, Francisco J.; Lapetra, José; Pintó, Xavier; Tur, Josep A.; Garcia-Rios, Antonio; García-Molina, Laura; Delgado-Rodriguez, Miguel; Matía-Martín, Pilar; Daimiel, Lidia; Vidal, Josep; Vázquez, Clotilde; Cofán, Montserrat; Romanos-Nanclares, Andrea; Becerra-Tomas, Nerea; Barragan, Rocio; Castañer, Olga; Konieczna, Jadwiga; González-Palacios, Sandra; Sorto-Sánchez, Carolina; Pérez-López, Jessica; Zulet, María A.; Bautista-Castaño, Inmaculada; Casas, Rosa; Gómez-Perez, Ana M.; Santos-Lozano, José M.; Rodríguez-Sanchez, María Á.; Julibert, Alicia; Martín-Calvo, Nerea; Hernández-Alonso, Pablo; Sorlí, José V; Sanllorente, Albert; Galmés-Panadés, Aina M.; Cases-Pérez, Eugenio; Goicolea-Güemez, Leire; Ruiz-Canela, Miguel; Babio, Nancy; Hernáez, Álvaro; Lamuela-Raventós, Rosa M.; Estruch, Ramon. 2020. "Dietary Polyphenol Intake is Associated with HDL-Cholesterol and A Better Profile of other Components of the Metabolic Syndrome: A PREDIMED-Plus Sub-Study" Nutrients 12, no. 3: 689.

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