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Open AccessArticle

Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling

1
Non-Clinical Evaluation Center, Biomedical Research Institute, Chonbuk National University Hospital, Jeonju, Chonbuk 54907, Korea
2
Research Institute of Clinical Medicine of Chonbuk National University-Biomedical Research Institute of Chonbuk National University Hospital, Jeonju, Chonbuk 54907, Korea
3
Department of Pharmacology, Chonbuk National University Medical School, Jeonju, Jeonbuk 54896, Korea
4
Department of Oral Pathology, School of Dentistry, Chonbuk National University, Jeonju, Chonbuk 54896, Korea
5
Jeju Institute of Korean Medicine, Jeju 63309, Korea
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(3), 673; https://doi.org/10.3390/nu12030673
Received: 15 January 2020 / Revised: 20 February 2020 / Accepted: 25 February 2020 / Published: 1 March 2020
(This article belongs to the Special Issue Nutrition and Metabolic (Non-alcoholic) Fatty Liver Disease (NAFLD))
Non-alcoholic fatty liver disease (NAFLD) is prevalent in the elderly population, and has symptoms ranging from liver steatosis to advanced fibrosis. Citrus peel extracts (CPEs) contain compounds that potentially improve dyslipidemia; however, the mechanism of action and effects on hepatic steatosis regulation remains unclear. Current study was aimed to investigate the protective effect of CPEs extracted through hot-air drying (CPEW) and freeze-drying (CPEF) and the underlying mechanism in a rat model of high-fat diet-induced NAFLD. The high-fat diet (HFD)-fed rats showed significant increase in total cholesterol, alanine aminotransferase (ALT), triglycerides, aspartate aminotransferase (AST), and lipid peroxidation compared to the normal chow-diet (NCD) group rats; but CPEW and CPEF limited this effect. CPEW and CPEF supplementation reduced both hepatocyte steatosis and fat accumulation involving the regulatory effect of mTORC1. Collectively, CPEW and CPEF protected deterioration of liver steatosis with AMPK activation and regulating ROS accumulation associated with interstitial disorders, which are also associated with endoplasmic reticulum (ER) redox. Thus, the application of CPEW and CPEF may lead to the development of novel therapeutic or preventive agents against NAFLD. View Full-Text
Keywords: citrus peel; NAFLD; high-fat diet; mTOR-ER stress; AMPK citrus peel; NAFLD; high-fat diet; mTOR-ER stress; AMPK
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MDPI and ACS Style

Lee, G.-H.; Peng, C.; Park, S.-A.; Hoang, T.-H.; Lee, H.-Y.; Kim, J.; Kang, S.-I.; Lee, C.-H.; Lee, J.-S.; Chae, H.-J. Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients 2020, 12, 673. https://doi.org/10.3390/nu12030673

AMA Style

Lee G-H, Peng C, Park S-A, Hoang T-H, Lee H-Y, Kim J, Kang S-I, Lee C-H, Lee J-S, Chae H-J. Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling. Nutrients. 2020; 12(3):673. https://doi.org/10.3390/nu12030673

Chicago/Turabian Style

Lee, Geum-Hwa; Peng, Cheng; Park, Seon-Ah; Hoang, The-Hiep; Lee, Hwa-Young; Kim, Junghyun; Kang, Seong-Il; Lee, Chi-Heon; Lee, Joo-Sang; Chae, Han-Jung. 2020. "Citrus Peel Extract Ameliorates High-Fat Diet-Induced NAFLD via Activation of AMPK Signaling" Nutrients 12, no. 3: 673. https://doi.org/10.3390/nu12030673

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