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Open AccessArticle

Characterising a Weight Loss Intervention in Obese Asthmatic Children

Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute, The University of Newcastle, New Lambton Heights, NSW 2305, Australia
Priority Research Centre Grow Up Well, Hunter Medical Research Institute, School of Medicine and Public Health, The University of Newcastle, New Lambton Heights, NSW 2305, Australia
Priority Research Centre in Physical Activity and Nutrition, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
Pediatric Respiratory and Sleep Medicine, John Hunter Children’s Hospital, New Lambton Heights, NSW 2305, Australia
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 507;
Received: 17 January 2020 / Revised: 6 February 2020 / Accepted: 7 February 2020 / Published: 17 February 2020
(This article belongs to the Special Issue Respiratory Disease and Nutrition)
The prevalence of obesity in asthmatic children is high and is associated with worse clinical outcomes. We have previously reported that weight loss leads to improvements in lung function and asthma control in obese asthmatic children. The objectives of this secondary analysis were to examine: (1) changes in diet quality and (2) associations between the baseline subject characteristics and the degree of weight loss following the intervention. Twenty-eight obese asthmatic children, aged 8–17 years, completed a 10-week diet-induced weight loss intervention. Dietary intake, nutritional biomarkers, anthropometry, lung function, asthma control, and clinical outcomes were analysed before and after the intervention. Following the intervention, the body mass index (BMI) z-score decreased (Δ = 0.18 ± 0.04; p < 0.001), %energy from protein increased (Δ = 4.3 ± 0.9%; p = 0.002), and sugar intake decreased (Δ = 23.2 ± 9.3 g; p= 0.025). Baseline lung function and physical activity level were inversely associated with Δ% fat mass. The ΔBMI z-score was negatively associated with physical activity duration at baseline. Dietary intervention is effective in achieving acute weight loss in obese asthmatic children, with significant improvements in diet quality and body composition. Lower lung function and physical engagement at baseline were associated with lesser weight loss, highlighting that subjects with these attributes may require greater support to achieve weight loss goals. View Full-Text
Keywords: weight loss; asthma; children; diet; nutritional biomarkers weight loss; asthma; children; diet; nutritional biomarkers
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Eslick, S.; Jensen, M.E.; Collins, C.E.; Gibson, P.G.; Hilton, J.; Wood, L.G. Characterising a Weight Loss Intervention in Obese Asthmatic Children. Nutrients 2020, 12, 507.

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