Next Article in Journal
A Delayed Morning and Earlier Evening Time-Restricted Feeding Protocol for Improving Glycemic Control and Dietary Adherence in Men with Overweight/Obesity: A Randomized Controlled Trial
Previous Article in Journal
Potential Health Claims of Durum and Bread Wheat Flours as Functional Ingredients
Open AccessArticle

Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women´s Weight: Possible Impact on Feto-Placental Vascular Function

1
Department of Obstetrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago 8330024, Chile
2
School of Medical Technology, Health Sciences Faculty, Universidad San Sebastian, Santiago 8330024, Chile
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(2), 506; https://doi.org/10.3390/nu12020506
Received: 30 December 2019 / Accepted: 11 February 2020 / Published: 17 February 2020
Gestational diabetes mellitus (GDM) associates with fetal endothelial dysfunction (ED), which occurs independently of adequate glycemic control. Scarce information exists about the impact of different GDM therapeutic schemes on maternal dyslipidemia and obesity and their contribution to the development of fetal-ED. The aim of this study was to evaluate the effect of GDM-treatments on lipid levels in nonobese (N) and obese (O) pregnant women and the effect of maternal cholesterol levels in GDM-associated ED in the umbilical vein (UV). O-GDM women treated with diet showed decreased total cholesterol (TC) and low-density lipoproteins (LDL) levels with respect to N-GDM ones. Moreover, O-GDM women treated with diet in addition to insulin showed higher TC and LDL levels than N-GDM women. The maximum relaxation to calcitonin gene-related peptide of the UV rings was lower in the N-GDM group compared to the N one, and increased maternal levels of TC were associated with even lower dilation in the N-GDM group. We conclude that GDM-treatments modulate the TC and LDL levels depending on maternal weight. Additionally, increased TC levels worsen the GDM-associated ED of UV rings. This study suggests that it could be relevant to consider a specific GDM-treatment according to weight in order to prevent fetal-ED, as well as to consider the possible effects of maternal lipids during pregnancy. View Full-Text
Keywords: GDM; cholesterol; glycemia; GDM treatment; vascular function GDM; cholesterol; glycemia; GDM treatment; vascular function
Show Figures

Figure 1

MDPI and ACS Style

Contreras-Duarte, S.; Carvajal, L.; Garchitorena, M.J.; Subiabre, M.; Fuenzalida, B.; Cantin, C.; Farías, M.; Leiva, A. Gestational Diabetes Mellitus Treatment Schemes Modify Maternal Plasma Cholesterol Levels Dependent to Women´s Weight: Possible Impact on Feto-Placental Vascular Function. Nutrients 2020, 12, 506.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop