Next Article in Journal
Modulation of Exercise-Induced Muscle Damage, Inflammation, and Oxidative Markers by Curcumin Supplementation in a Physically Active Population: A Systematic Review
Previous Article in Journal
Impact of the Co-Administration of N-3 Fatty Acids and Olive Oil Components in Preclinical Nonalcoholic Fatty Liver Disease Models: A Mechanistic View
Previous Article in Special Issue
The Role of Vitamin D and Omega-3 PUFAs in Islet Transplantation
Open AccessReview

Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease

1
Department of Paediatrics and NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands
2
Department of Dietetics, Maastricht University Medical Centre, P. Debyelaan 25, 6229 HX Maastricht, The Netherlands [email protected]
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 500; https://doi.org/10.3390/nu12020500
Received: 3 January 2020 / Revised: 5 February 2020 / Accepted: 13 February 2020 / Published: 15 February 2020
Nutrient deficiencies are well recognized as secondary consequences of celiac disease (CD) and closely related to the clinical presentation of affected patients. Despite their clinical significance, consensus is lacking on the pattern and frequency of nutrient deficiencies in CD, the usefulness of their assessment at the time of diagnosis and during follow-up. This review aims to provide an overview of nutrient deficiencies among pediatric and adult CD patients at diagnosis and on a gluten-free diet (GFD), and their potential causes in CD. Secondly, we review their impact on CD management strategies including the potential of nutrient supplementation. A search of Medline, Pubmed and Embase until January 2019 was performed. Despite a high variability between the reported deficiencies, we noted that nutrient deficiencies occur frequently in children and adults with CD at diagnosis and during treatment with a GFD. Both inadequate dietary intake and/or diminished uptake due to intestinal dysfunction contribute to nutrient deficiencies. Most deficiencies can be restored with (long-term) treatment with a GFD and/or supplementation. However, some of them persist while others may become even more prominent during GFD. Our results indicate a lack of comprehensive evidence on the clinical efficacy of nutrient supplementation in CD management highlighting the need for further studies. View Full-Text
Keywords: celiac disease; gluten free diet; nutrient deficiencies; nutritional status; supplementation celiac disease; gluten free diet; nutrient deficiencies; nutritional status; supplementation
Show Figures

Figure 1

MDPI and ACS Style

Kreutz, J.M.; Adriaanse, M.P.M.; van der Ploeg, E.M.C.; Vreugdenhil, A.C.E. Narrative Review: Nutrient Deficiencies in Adults and Children with Treated and Untreated Celiac Disease. Nutrients 2020, 12, 500.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop