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Open AccessArticle

Effects of A 12-Month Intensive Lifestyle Monitoring Program in Predominantly Overweight/Obese Arab Adults with Prediabetes

1
Biochemistry Department, Chair for Biomarkers of Chronic Diseases, King Saud University, Riyadh 11451, Saudi Arabia
2
Department of Food Science and Nutrition, College of Food Science and Agriculture, King Saud University, Riyadh 11451, Saudi Arabia
3
Diabetes Centres and Units Administration, Ministry of Health, Riyadh 11176, Saudi Arabia
4
First Department of Pediatrics, Medical School, National and Kapodistrian University of Athens, 15772 Athens, Greece
5
Division of Biomedical Sciences, Warwick Medical School, University of Warwick, Coventry CV4 7HL, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(2), 464; https://doi.org/10.3390/nu12020464
Received: 19 December 2019 / Revised: 5 February 2020 / Accepted: 10 February 2020 / Published: 12 February 2020
(This article belongs to the Section Clinical Nutrition)
This 12-month, randomized, controlled lifestyle intervention study was aimed at assessing the effectiveness of a lifestyle intervention in terms of (1) the reduction of at least 5% of body weight compared to baseline and (2) the percentage of participants in which fasting blood glucose (FBG) normalizes (<5.6 mmol/L) post-intervention, in predominantly overweight/obese Saudi adults with impaired fasting glucose. A total of 300 Saudi adults with prediabetes at baseline (FBG 5.6–6.9 mmol/L) were enrolled to receive either general advice (GA) or a rigorous, self-monitored, lifestyle modification program (intervention group, IG) for 12 months, focused on food choices, physical activity, and weight loss. Anthropometric and biochemical estimations were analyzed at baseline, 6, and 12 months. At baseline, 136/150 in the GA group (90.7%) and 127/150 in the IG group (84.7%) were either overweight or obese. A total of 14% (n = 21) of the subjects in the IG arm discontinued, compared to 8% (n = 12) in the GA arm. Data from completers (92% (n = 138) and 86% (n= 129) participants in GA and IG arms, respectively) were considered for the final analysis. Post-intervention, 37.2% (n = 48) of participants in the IG group had ≥5% weight reduction, as compared to 12.3% (n = 17) in the GA group (p < 0.01). Similarly, the percentage of participants who normalized their FBG post-intervention was 46.5% (n = 60) in the IG group compared to 21.7% (n = 30) in the GA group (p < 0.01). A 12-month Diabetes Prevention Program (DPP)-styled intensive lifestyle program translated effectively in decreasing weight and improving fasting glucose compared to the GA group in predominantly overweight/obese Saudi adults with prediabetes, suggesting that in the case of guided intervention programs, people are willing to participate and possibly change a sedentary lifestyle.
Keywords: lifestyle intervention; type 2 diabetes; impaired glucose regulation; fasting blood glucose; physical activity; dietary modifications lifestyle intervention; type 2 diabetes; impaired glucose regulation; fasting blood glucose; physical activity; dietary modifications
MDPI and ACS Style

Wani, K.; Alfawaz, H.; Alnaami, A.M.; Sabico, S.; Khattak, M.N.K.; Al-Attas, O.; Alokail, M.S.; Alharbi, M.; Chrousos, G.; Kumar, S.; Al-Daghri, N.M. Effects of A 12-Month Intensive Lifestyle Monitoring Program in Predominantly Overweight/Obese Arab Adults with Prediabetes. Nutrients 2020, 12, 464.

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