Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Nutritional Assessment
2.3. Dietary Indices Calculation
2.4. Blood Biochemical Analyses
2.5. Fecal Collection and Microbial Analysis
2.6. Statistical Analyses
3. Results
4. Discussion
5. Conclusions
Supplementary Materials
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Variable | n | DII | EDII | HEI | AHEI | DQI-I | rMED | MMDS |
---|---|---|---|---|---|---|---|---|
Mean (IQR) | −0.35 (1.07–−2.25) | 0.67 (1.17–0.19) | 58.16 (65.68–49.95) | 60.99 (67.97–55.08) | 49.03 (55–44) | 7.16 (9–6) | 3.37 (4–2) | |
Gender | ||||||||
Male | 20 | −1.04 ± 2.27 a | 0.64 ± 0.73 a | 55.92 ± 11.47 a | 63.48 ± 8.51 a | 47.15 ± 9.53 a | 7.80 ± 2.48 a | 3,65 ± 1,31 a |
Female | 53 | −0.10 ± 2.54 a | 0.68 ± 0.78 a | 59.00 ± 10.00 a | 60.10 ± 10.52 a | 49.74 ± 7.04 a | 6.92 ± 2.28 a | 3.26 ± 1.46 a |
Age (years) | ||||||||
50–65 | 33 | −1.92 ± 2.05 a | 0.24 ± 0.62 a | 62.63 ± 9.01 a | 64.07 ± 8.94 a | 51.97 ± 0.83 a | 8.39 ± 2.14 a | 3.67 ± 1.29 a |
>65 | 40 | 0.98 ± 2.02 b | 1.02 ± 0.69 b | 54.46 ± 10.16 b | 58.39 ± 10.37 b | 46.60 ± 5.96 b | 6.15 ± 2.03 b | 3.13 ± 1.49 a |
Energy intake (kcal/day) | ||||||||
≤1538.9 | 25 | 0.01 ± 2.3 a,b | 0.41 ± 0.67 a | 58.95 ± 11.43 a | 63.49 ± 8.21 a | 46.36 ± 7.76 a | 7.08 ± 2.33 a | 3.52 ± 1.66 a |
1539–1994.8 | 24 | 0.40 ± 2.19 a | 0.77 ± 0.62 a | 57.22 ± 9.42 a | 60.17 ± 9.80 a | 47.46 ± 7.17 a | 6.79 ± 1.86 a | 3 ± 1.02 a |
>1994.9 | 24 | −1.47 ± 2.65 b | 0.84 ± 0.92 a | 58.27 ± 10.67 a | 59.32 ± 11.84 a | 53.38 ± 6.88 b | 7.63 ± 2.76 a | 3.58 ± 1.47 a |
BMI (kg/m2) | ||||||||
<25 | 19 | −0.99 ± 2.77 a | 0.37 ± 0.72 a | 10.02 ± 19 a | 62.74 ± 9.90 a | 48.95 ± 9.20 a | 7.79 ± 2.32 a | 3.68 ± 1.60 a |
25.0–29.9 | 37 | −0.39 ± 2.37 a | 0.62 ± 0.77 a.b | 10.10 ± 37 a | 61.83 ± 10.16 a | 48.43 ± 7.65 a | 7.11 ± 2.50 a | 3.22 ± 1.38 a |
≥30 | 17 | 0.44 ± 2.33 a | 1.10 ± 0.62 b | 10.35 ± 17 a | 57.28 ± 9.77 a | 50.41 ± 6.75 a | 6.59 ± 1.97 a | 3.35 ± 1.32 a |
Depositions (times/week) | ||||||||
≤3 | 8 | 0.51 ± 2.12 a | 0.85 ± 0.58 a | 53.09 ± 12.71 a | 60.29 ± 6.12 a | 47.50 ± 7.96 a | 7.00 ± 2.51 a | 3.00 ± 1.60 a |
>3–7 | 57 | −0.11 ± 2.48 a | 0.71 ± 0.76 a | 58.40 ± 10.02 a | 60.74 ± 10.44 a | 49.19 ± 7.89 a | 6.93 ± 2.34 a | 3.35 ± 1.38 a |
>7 | 8 | −2.82 ± 1.28 a | 0.16 ± 0.85 b | 61.51 ± 10.59 a | 63.44 ± 10.92 a | 49.38 ± 8.07 a | 9.00 ± 1.51 a | 3.88 ± 1.55 a |
Smoking status | ||||||||
Never | 9 | −2.27 ± 1.74 a | 0.11 ± 0.51 a | 67.14 ± 8.34 a | 64.66 ± 7.90 a | 49.22 ± 10.94 a | 8.78 ± 2.54 a | 4.0 ± 1.32 a |
Current | 17 | −0.40 ± 2.55 a | 0.63 ± 0.67 a | 60.79 ± 9.12 a | 61.14 ± 8.21 a | 50.35 ± 6.72 a | 7.53 ± 2.24 a | 3.65 ± 1.37 a |
Former | 16 | −1.11 ± 2.04 a | 0.38 ± 0.59 a | 60.17 ± 10.28 a | 65.93 ± 7.43 a | 49.81 ± 8.23 a | 8.25 ± 1.77 a | 3.75 ± 1.18 a |
Educational level | ||||||||
None or primary school | 2 | −2.46 ± 0.42 a | 0.45 ± 0.49 a | 66.19 ± 5.27 a | 63.13 ± 7.38 a | 57.00 ± 7.07 a | 7.00 ± 1.41 a | 3.50 ± 0.71 a |
Technical school | 5 | −1.73 ± 1.80 a | −0.03 ± 0.34 a | 63.81 ± 6.21 a | 63.80 ± 1.99 a | 51.60 ± 6.35 a | 9.60 ± 1.67 a | 3.20 ± 1.10 a |
Secondary school | 7 | −1.40 ± 2.86 a | 0.37 ± 0.65 a | 59.20 ± 8.96 a | 60.29 ± 8.83 a | 54.00 ± 8.06 a | 7.71 ± 2.75 a | 3.29 ± 1.25 a |
University degree | 13 | −2.00 ± 1.61 a | 0.19 ± 0.46 a | 63.55 ± 9.67 a | 66.63 ± 7.77 a | 48.85 ± 9.14 a | 8.54 ± 1.90 a | 4.00 ± 1.22 a |
Mood feeling | ||||||||
Really satisfied | 42 | −0.35 ± 2.61 a | 0.70 ± 0.81 a | 57.99 ± 10.07 a | 60.63 ± 9.90 a | 48.88 ± 8.16 a | 7.24 ± 2.54 a | 3.48 ± 1.45 a |
Satisfied | 21 | −0.68 ± 2.28 a | 0.57 ± 0.65 a | 61.28 ± 10.14 a | 63.27 ± 10.61 a | 49.48 ± 7.61 a | 7.76 ± 1.84 a | 3.38 ± 1.40 a |
Unsatisfied | 8 | 0.96 ± 2.17 a | 0.78 ± 0.58 a | 51.65 ± 11.64 a | 57.86 ± 7.67 a | 46.75 ± 6.90 a | 5.25 ± 1.98 a | 2.63 ± 1.30 a |
Self-health perception | ||||||||
Excellent-good | 42 | −0.01 ± 2.20 a | 0.75 ± 0.72 a | 57.17 ± 9.85 a | 59.24 ± 7.88 a | 47.12 ± 7.15 a | 6.95 ± 2.39 a,b | 3.26 ± 1.31 a,b |
Normal | 18 | −1.53 ± 2.54 a | 0.51 ± 0.68 a | 61.38 ± 101.39 a | 66.44 ± 10.49 b | 52.28 ± 7.89 a | 8.33 ± 2.22 a | 4.00 ± 1.57 a |
Bad | 12 | 0.56 ± 2.76 a | 0.75 ± 0.95 a | 56.43 ± 11.15 a | 58.14 ± 13.62 a,b | 49.92 ± 8.40 a | 6.08 ± 1.88 b | 2.67 ± 1.23 b |
Variable | Age Groups | |
---|---|---|
G1 (≤65) (n = 33) | G2 (>65) (n = 40) | |
Akkermansia (Log10 n° cells/gram feces) | 6.43 ± 1.88 a | 6.99 ± 1.77 a |
Bacteroides-Prevotella-Porphyromonas (Log10 n° cells/gram feces) | 9.32 ± 0.82 a | 8.79 ± 0.69 b |
Bifidobacterium (Log10 n° cells/gram feces) | 7.93 ± 1.53 a | 7.55 ± 1.10 a |
Clostridia cluster XIVa (Log10 n° cells/gram feces) | 7.57 ± 1.49 a | 6.45 ± 1.54 b |
Lactobacillus group (Log10 n° cells/gram feces) | 5.91 ± 1.26 a | 6.97 ± 1.83 b |
Faecalibacterium prausnitzii (Log10 n° cells/gram feces) | 7.07 ± 0.76 a | 6.42 ± 1.31 b |
Acetic acid (mM) | 29.81 ± 9.25 a | 23.18 ± 14.45 b |
Propionic acid (mM) | 12.94 ± 5.43 a | 9.50 ± 7.46 b |
Butyric acid (mM) | 11.76 ± 9.39 a | 8.44 ± 7.94 a |
Glucose (mg/dL) | 97.76 ± 12.99 a | 106.78 ± 33.85 a |
Triglycerides (mg/dL) | 118.82 ± 54.23 a | 121.75 ± 48.41 a |
Cholesterol (mg/dL) | 233.18 ± 39.06 a | 203.39 ± 37.48 b |
LDL-HDL ratio | 2.76 ± 0.78 a | 2.72 ± 0.81 a |
Leptin (ng/mL) | 9.62 ± 5.72 a | 12.01 ± 7.87 a |
Serum MDA (μM) | 2.01 ± 0.53 a | 2.60 ± 0.49 b |
Antioxidant capacity (mM) | 0.34 ± 0.09 a | 0.35 ± 0.09 a |
CRP (mg/L) | 1.28 ± 1.22 a | 1.19 ± 1.03 a |
TGF-β (ng/mL) | 4.44 ± 2.71 a | 6.25 ± 5.70 a |
IL-10 (pg/mL) | 0.14 ± 0.78 a | 0.80 ± 3.70 a |
IL-17 (pg/mL) | 1.42 ± 3.10 a | 2.28 ± 11.57 a |
IL-8 (pg/mL) | 7.09 ± 6.01 a | 20.80 ± 9.91 b |
IL-12 (pg/mL) | 0.21 ± 1.21 a | 3.54 ± 8.92 b |
TNF-α (pg/mL) | 0.23 ± 1.23 a | 4.82 ± 7.94 b |
Phagocytosis granulocytes (%) | 72.23 ± 22.13 a | 86.37 ± 18.53 a |
Phagocytosis granulocytes and monocytes (%) | 71.39 ± 21.32 a | 82.35 ± 17.49 a |
NK cell activity (%) | 53.09 ± 11.25 a | 52.70 ± 18.19 a |
Dependent Variable | Independent Variable | R2 | β | p | |
---|---|---|---|---|---|
Model 1. Fecal microbiota groups Akkermansia, Bacteroides-Prevotella-Porphyromonas, Bifidobacterium, Clostridia cluster XIVa, Faecalibacterium prausnitzii, Lactobacillus group | Akkermansia | HEI | 0.080 | −0.307 | 0.026 |
AHEI | 0.059 | −0.256 | 0.050 | ||
DQI-I | 0.072 | −0.285 | 0.038 | ||
Faecalibacterium prausnitzii | DII | 0.124 | −0.312 | 0.030 | |
HEI | 0.128 | 0.284 | 0.035 | ||
DQI-I | 0.122 | 0.265 | 0.047 | ||
MMDS | 0.123 | 0.240 | 0.044 | ||
Lactobacillus group | AHEI | 0.264 | −0.256 | 0.027 | |
MMDS | 0.283 | −0.275 | 0.012 | ||
Model 2. Fecal short chain fatty acids Acetic acid, Propionic acid, Butyric acid | Acetic acid | DII | 0.252 | −0.425 | 0.003 |
EDII | 0.244 | −0.369 | 0.013 | ||
HEI | 0.239 | 0.320 | 0.016 | ||
AHEI | 0.335 | 0.478 | 0.000 | ||
MMDS | 0.356 | 0.451 | 0.000 | ||
Propionic acid | DII | 0.198 | −0.316 | 0.031 | |
HEI | 0.246 | 0.348 | 0.009 | ||
AHEI | 0.303 | 0.441 | 0.000 | ||
MMDS | 0.292 | 0.378 | 0.001 | ||
Butyric acid | HEI | 0.189 | 0.289 | 0.034 | |
AHEI | 0.213 | 0.338 | 0.007 | ||
MMDS | 0.211 | 0.298 | 0.012 | ||
Model 3. Blood biomarkers Glucose, Triglycerides, LDL-HDL ratio, Leptin, Serum malondialdehyde (MDA), Antioxidant capacity, C-Reactive protein (CRP), Transforming growth factor-beta (TGF-β), IL-10, IL-17, IL-8, IL-12, TNF-α, % Phagocytosis granulocytes, % Phagocytosis granulocytes and monocytes, NK cell activity | MDA | DII | 0.297 | 0.373 | 0.003 |
EDII | 0.318 | 0.408 | 0.002 | ||
IL-8 | rMED | 0.443 | −0.251 | 0.018 | |
MMDS | 0.443 | −0.221 | 0.017 |
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Ruiz-Saavedra, S.; Salazar, N.; Suárez, A.; de los Reyes-Gavilán, C.G.; Gueimonde, M.; González, S. Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects. Nutrients 2020, 12, 3828. https://doi.org/10.3390/nu12123828
Ruiz-Saavedra S, Salazar N, Suárez A, de los Reyes-Gavilán CG, Gueimonde M, González S. Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects. Nutrients. 2020; 12(12):3828. https://doi.org/10.3390/nu12123828
Chicago/Turabian StyleRuiz-Saavedra, Sergio, Nuria Salazar, Ana Suárez, Clara G. de los Reyes-Gavilán, Miguel Gueimonde, and Sonia González. 2020. "Comparison of Different Dietary Indices as Predictors of Inflammation, Oxidative Stress and Intestinal Microbiota in Middle-Aged and Elderly Subjects" Nutrients 12, no. 12: 3828. https://doi.org/10.3390/nu12123828