The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity
Abstract
:1. Introduction
2. Materials and Methods
3. Participants
4. Magnetic Resonance Imaging
5. Biochemical Measurements
6. Statistics
7. Results
7.1. Characteristics
7.2. Regional Adipose Tissue Deposition
7.3. Inflammatory Markers
7.4. Relationships between Inflammatory Markers and Regional Adipose Depots
8. Discussion
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
Abbreviations
BWA | black West African |
BMI | body mass index |
CV | coefficient of variation |
dSAT | deep subcutaneous adipose tissue |
HbA1c | glycated haemoglobin |
IFN | Interferon |
IL | Interleukin |
MRI | magnetic resonance imaging |
SAT | subcutaneous adipose tissue |
sSAT | superficial subcutaneous adipose tissue |
T2D | type 2 diabetes |
TNF | tumour necrosis factor |
VEGF | vascular endothelial growth factor |
VAT | visceral adipose tissue |
WE | white European |
ASAT | abdominal subcutaneous adipose tissue |
BP | blood pressure |
dSAT | deep subcutaneous adipose tissue |
HDL | high-density lipoprotein |
LDL | low-density lipoprotein |
NGT | normal glucose tolerance |
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NGT | T2D | ||||||
---|---|---|---|---|---|---|---|
WE (n = 23) | BWA (n = 23) | WE (n = 19) | BWA (n = 20) | P eth | P gly | P eth*gly | |
Age (years) * | 33.5 (28.4–39.5) | 28.8 (24.6–33.7) | 55.7 (52.3–59.3) | 53.8 (50.2–57.8) | 0.15 | <0.001 | 0.36 |
Weight (kg) | 86.5 ± 16.5 | 84.1 ± 14.6 | 100.6 ± 16.7 | 92.4 ± 11.8 | 0.11 | 0.001 | 0.38 |
BMI (kg/m2) | 26.5 ± 4.5 | 26.7 ± 3.6 | 31.9 ± 4.3 | 30.0 ± 3.5 | 0.34 | <0.001 | 0.24 |
Waist circumference (cm) | 93.8 ± 14.6 | 87.5 ± 9.2 | 112.3 ± 12.7 | 104.9 ± 9.7 | 0.009 | <0.001 | 0.83 |
HbA1c (%) | 5.44 ± 0.24 | 5.54 ± 0.48 | 6.68 ± 0.74 | 6.76 ± 0.70 | 0.46 | <0.001 | 0.94 |
HbA1c (mmol/mol) | 35.9 ± 2.9 | 37.0 ± 5.27 | 49.5 ± 8.19 | 50.4 ± 7.80 | 0.45 | <0.001 | 0.94 |
Fasting plasma glucose (mmol/l) | 5.20 ± 0.39 | 5.13 ± 0.44 | 6.95 ± 1.35 | 6.71 ± 0.96 | 0.39 | <0.001 | 0.63 |
Systolic BP (mm Hg) | 121.9 ± 9.1 | 123.1 ± 12.3 | 132.1 ± 13.0 | 137.5 ± 13.7 | 0.21 | <0.001 | 0.42 |
Diastolic BP (mm Hg) | 71.1 ± 8.2 | 70.7 ± 11.5 | 82.6 ± 9.1 | 86.1 ± 7.4 | 0.45 | <0.001 | 0.34 |
Total cholesterol (mmol/l) | 4.76 ± 1.1 | 4.27 ± 1.1 | 4.41 ± 0.83 | 4.09 ± 0.70 | 0.051 | 0.19 | 0.68 |
LDL cholesterol (mmol/l) | 2.99 ± 0.82 | 2.66 ± 0.87 | 2.34 ± 0.69 | 2.32 ± 0.53 | 0.27 | 0.003 | 0.35 |
HDL cholesterol (mmol/l) | 1.27 ± 0.31 | 1.30 ± 0.42 | 1.22 ± 0.25 | 1.18 ± 0.37 | 0.97 | 0.23 | 0.62 |
Triglyceride (mmol/l) * | 1.09 (0.86–1.33) | 0.68 (0.57–0.79) | 1.83 (1.41–2.26) | 1.27 (0.94–1.61) | <0.001 | <0.001 | 0.66 |
Regional adipose tissue | |||||||
VAT (cm2) *,a | 79.0 (55–112) | 46.1 (34–61) | 184.4 (148–229) | 128.1 (103–159) | 0.002 | <0.001 | 0.54 |
ASAT (cm2) *,a | 193.2 (149–249) | 181.9 (136–243) | 291.0 (243–348) | 285.6 (247–330) | 0.73 | <0.001 | 0.85 |
VAT:ASAT *,a | 0.46 (0.34–0.59) | 0.30 (0.20–0.39) | 0.70 (0.52–0.87) | 0.48 (0.39–0.58) | 0.002 | <0.001 | 0.70 |
dSAT (cm2) *,a | 109.8 (76–159) | 102.6 (73–145) | 188.6 (159–223) | 175.3 (150–205) | 0.63 | <0.001 | 0.99 |
sSAT (cm2) *,a | 75.5 (62–93) | 76.6 (60–97) | 100.5 (81–125) | 108.8 (93–127) | 0.64 | 0.002 | 0.74 |
dSAT:sSAT a | 1.68 ± 0.84 | 1.42 ± 0.49 | 1.93 ± 0.47 | 1.65 ± 0.35 | 0.047 | 0.075 | 0.92 |
Inflammatory markers | |||||||
Adiponectin (mg/L) * | 4.61 (3.89–5.37) | 3.41 (2.64–4.22) | 3.33 (2.46–4.26) | 2.44 (1.88–3.02) | 0.005 | 0.003 | 0.76 |
Leptin (µg/L) *,b | 5.19 (3.44–7.83) | 6.55 (4.42–9.70) | 10.9 (7.7–15.5) | 9.0 (6.8–12.0) | 0.92 | 0.003 | 0.23 |
IL-6 (ng/L) * | 0.99 (0.73–1.25) | 0.95 (0.73–1.17) | 1.32 (1.05–1.59) | 1.18 (0.87–1.50) | 0.49 | 0.030 | 0.71 |
TNF-α (ng/L) c | 2.48 ± 0.54 | 2.39 ± 0.75 | 3.03 ± 0.80 | 2.49 ± 0.55 | 0.034 | 0.033 | 0.13 |
IL-10 (ng/L) *,d | 0.57 (0.44–0.70) | 0.75 (0.62–0.88) | 0.51 (0.41–0.61) | 0.63 (0.49–0.80) | 0.019 | 0.16 | 0.60 |
Resistin (µg/L) *,e | 4.07 (3.57–4.63) | 4.38 (3.68–5.21) | 3.51 (3.00–4.11) | 3.81 (3.13–4.64) | 0.32 | 0.073 | 0.95 |
IFN-γ (ng/L) *,f | 4.29 (3.62–5.07) | 5.03 (4.04–6.26) | 5.88 (4.7–7.3) | 4.08 (2.6–6.4) | 0.38 | 0.65 | 0.027 |
IL-8 (ng/L) g | 8.44 ± 3.62 | 8.15 ± 2.16 | 9.86 ± 4.50 | 11.0 ± 3.96 | 0.59 | 0.008 | 0.37 |
VEGF (ng/L) * | 51.3 (37.6–70.0) | 60.1 (43.4–83.2) | 83.2 (62.5–110.7) | 90.7 (65.5–125.5) | 0.43 | 0.004 | 0.82 |
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Hakim, O.; Bello, O.; Ladwa, M.; Peacock, J.L.; Umpleby, A.M.; Charles-Edwards, G.; Amiel, S.A.; Goff, L.M. The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity. Nutrients 2020, 12, 3796. https://doi.org/10.3390/nu12123796
Hakim O, Bello O, Ladwa M, Peacock JL, Umpleby AM, Charles-Edwards G, Amiel SA, Goff LM. The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity. Nutrients. 2020; 12(12):3796. https://doi.org/10.3390/nu12123796
Chicago/Turabian StyleHakim, Olah, Oluwatoyosi Bello, Meera Ladwa, Janet L. Peacock, A. Margot Umpleby, Geoffrey Charles-Edwards, Stephanie A. Amiel, and Louise M. Goff. 2020. "The Link between Obesity and Inflammatory Markers in the Development of Type 2 Diabetes in Men of Black African and White European Ethnicity" Nutrients 12, no. 12: 3796. https://doi.org/10.3390/nu12123796