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Review

Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review

Department of Internal Medicine, School of Medicine, Keio University, Tokyo 160-8582, Japan
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3846; https://doi.org/10.3390/nu12123846
Received: 16 November 2020 / Revised: 14 December 2020 / Accepted: 14 December 2020 / Published: 16 December 2020
(This article belongs to the Special Issue Nutrition and Lipid Metabolism in Type 2 Diabetes)
Type 2 diabetes (T2DM) is characterized by insulin resistance and beta-cell dysfunction. Although insulin resistance is assumed to be a main pathophysiological feature of the development of T2DM, recent studies have revealed that a deficit of functional beta-cell mass is an essential factor for the pathophysiology of T2DM. Pancreatic fat contents increase with obesity and are suggested to cause beta-cell dysfunction. Since the beta-cell dysfunction induced by obesity or progressive decline with disease duration results in a worsening glycemic control, and treatment failure, preserving beta-cell mass is an important treatment strategy for T2DM. In this mini-review, we summarize the current knowledge on beta-cell mass, beta-cell function, and pancreas fat in obesity and T2DM, and we discuss treatment strategies for T2DM in relation to beta-cell preservation. View Full-Text
Keywords: beta-cell mass; diabetes; obesity; pancreas fat; human pancreas beta-cell mass; diabetes; obesity; pancreas fat; human pancreas
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MDPI and ACS Style

Inaishi, J.; Saisho, Y. Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review. Nutrients 2020, 12, 3846. https://doi.org/10.3390/nu12123846

AMA Style

Inaishi J, Saisho Y. Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review. Nutrients. 2020; 12(12):3846. https://doi.org/10.3390/nu12123846

Chicago/Turabian Style

Inaishi, Jun, and Yoshifumi Saisho. 2020. "Beta-Cell Mass in Obesity and Type 2 Diabetes, and Its Relation to Pancreas Fat: A Mini-Review" Nutrients 12, no. 12: 3846. https://doi.org/10.3390/nu12123846

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