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Article

Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019

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Department of Endocrinology-Diabetology-Nutrition, AP-HP Avicenne Hospital, 93000 Bobigny, France
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Department of Infectious Disease, AP-HP Avicenne Hospital, 93000 Bobigny, France
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Department of Rehabilitation Nutrition-Obesity, AP-HP René Muret Hospital, 93270 Sevran, France
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LEPS (Laboratoire Educations et Pratiques de Santé) EA 3412, Université Paris 13, 93000 Bobigny, France
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Department of Internal Medicine, AP-HP Avicenne Hospital, 93000 Bobigny, France
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Laboratory for Vascular Translational Science (LVTS), Inserm U1148 Groupe Biothérapies et Glycoconjugués/Université Paris 13—Sorbonne Paris Nord, 93000 Bobigny, France
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Department of Biology Laboratory, AP-HP Avicenne Hospital, 93000 Bobigny, France
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eXYSTAT, 92240 Malakoff, France
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Department of Respiratory Disease, AP-HP Avicenne Hospital, 93000 Bobigny, France
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Department of Gastroenterology and Digestive Oncology, AP-HP Avicenne Hospital, 93000 Bobigny, France
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Equipe de Recherche en Epidémiologie Nutritionnelle (EREN), UMR U1153 Inserm/U1125 Inrae/Cnam/Université Paris 13—Sorbonne Paris Nord, Centre de Recherche en Epidémiologie et Statistiques—Université de Paris (CRESS), EREN, SMBH PARIS 13, 93000 Bobigny, France
*
Author to whom correspondence should be addressed.
These authors contributed equally to this work.
Nutrients 2020, 12(12), 3679; https://doi.org/10.3390/nu12123679
Received: 31 October 2020 / Revised: 19 November 2020 / Accepted: 25 November 2020 / Published: 28 November 2020
(This article belongs to the Section Clinical Nutrition)
Previous studies have found a correlation between malnutrition and prognosis in respiratory infections. Our objectives were to determine (i) the percentage of malnutrition, and (ii) its prognosis in patients admitted for coronavirus disease 2019 (COVID-19). In this monocentric retrospective study, we consecutively included all adult patients presenting with acute COVID-19 between 9 April and 29 May 2020. Malnutrition was diagnosed on low body mass index (BMI) and weight loss ≥ 5% in the previous month and/or ≥ 10% in the previous six months. The Nutritional Risk Index (NRI) defined nutritional risk. Severe COVID-19 was defined as a need for nasal oxygen ≥ 6 L/min. We enrolled 108 patients (64 men, 62 ± 16 years, BMI 28.8 ± 6.2 kg/m2), including 34 (31.5%) with severe COVID-19. Malnutrition was found in 42 (38.9%) patients, and moderate or severe nutritional risk in 83 (84.7%) patients. Malnutrition was not associated with COVID-19 severity. Nutritional risk was associated with severe COVID-19 (p < 0.01; p < 0.01 after adjustment for C reactive protein), as were lower plasma proteins, albumin, prealbumin, and zinc levels (p < 0.01). The main cause of malnutrition was inflammation. The high percentage of malnutrition and the association between nutritional risk and COVID-19 prognosis supports international guidelines advising regular screening and nutritional support when necessary. View Full-Text
Keywords: malnutrition; nutritional risk; COVID-19; prognosis malnutrition; nutritional risk; COVID-19; prognosis
MDPI and ACS Style

Allard, L.; Ouedraogo, E.; Molleville, J.; Bihan, H.; Giroux-Leprieur, B.; Sutton, A.; Baudry, C.; Josse, C.; Didier, M.; Deutsch, D.; Bouchaud, O.; Cosson, E. Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019. Nutrients 2020, 12, 3679. https://doi.org/10.3390/nu12123679

AMA Style

Allard L, Ouedraogo E, Molleville J, Bihan H, Giroux-Leprieur B, Sutton A, Baudry C, Josse C, Didier M, Deutsch D, Bouchaud O, Cosson E. Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019. Nutrients. 2020; 12(12):3679. https://doi.org/10.3390/nu12123679

Chicago/Turabian Style

Allard, Lucie, Elise Ouedraogo, Julie Molleville, Helene Bihan, Bénédicte Giroux-Leprieur, Angela Sutton, Camille Baudry, Constant Josse, Morgane Didier, David Deutsch, Olivier Bouchaud, and Emmanuel Cosson. 2020. "Malnutrition: Percentage and Association with Prognosis in Patients Hospitalized for Coronavirus Disease 2019" Nutrients 12, no. 12: 3679. https://doi.org/10.3390/nu12123679

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