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Article

Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults

1
Institute of Molecular and Translational Medicine, Faculty of Medicine and Dentistry, Palacky University, Hněvotínská 1333/5, 779 00 Olomouc, Czech Republic
2
Department of Medicine, Division of Experimental Medicine, McGill University, 1001 DeCarie Boulevard EM 23242, Montreal, QC H4A 3J1, Canada
3
The Research Institute of the McGill University Health Centre, Infectious Diseases and Immunity in the Global Health Program, 1001 DeCarie Boulevard EM 23242, Montreal, QC H4A 3J1, Canada
4
Department of Genetics, McGill University, 1001 DeCarie Boulevard EM 23242, Montreal, QC H4A 3J1, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(12), 3641; https://doi.org/10.3390/nu12123641
Received: 11 October 2020 / Revised: 17 November 2020 / Accepted: 25 November 2020 / Published: 26 November 2020
(This article belongs to the Special Issue Immune Function and Nutrient Supplementation)
(1) Background: In the healthy ageing, NK cell number is not modified; however, their spontaneous cytotoxicity decreases. We postulated that the age-dependent decline in metabolic activities might be responsible for this effect. (2) Methods: The fatty acid profile of 30 healthy young males (23 ± 4 years old, BMI 22.1 ± 1.3) and 30 older males (63 ± 5 years old, BMI 22.9 ± 2.5) donors were evaluated along with the expression of killing (KR) and inhibitory NK receptors (KIR) at basal level and after cultivation with fatty acids for 24 h. (3) Results: Significantly higher levels of oleic (p < 0.01), arachidonic (p < 0.001), lignoceric (p < 0.001), and nervonic acids (p < 0.0001) and significantly lower levels of docosapentaenoic and docosahexaenoic acids (p < 0.01) were found in elders as compared to young adults. At basal levels, significant (p < 0.005) differences in KR and KIR expression were encountered; 12/16 antigens. Treatment of cells with saturated fatty acids or arachidonic acid (AA) significantly enhanced KR expressions (p < 0.001). AA treatment decreased inhibitory KIR expression while docosahexaenoic, and eicosapentaenoic acid increased them. (4) Conclusions: Changes in fatty acids blood levels, and KR and KIR expression in NK cell, are age-dependent. Supplementation of NK cells with eicosapentaenoic or docosahexaenoic acid enhanced inhibitory KIR receptors’ expression which may improve their cell function. View Full-Text
Keywords: natural killer cells; ageing; saturated fatty acids; unsaturated fatty acids; killing activating receptors; killing inhibitory receptors (KIR) natural killer cells; ageing; saturated fatty acids; unsaturated fatty acids; killing activating receptors; killing inhibitory receptors (KIR)
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MDPI and ACS Style

De Sanctis, J.B.; Dumut, D.C.; Radzioch, D.; Hajdúch, M. Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults. Nutrients 2020, 12, 3641. https://doi.org/10.3390/nu12123641

AMA Style

De Sanctis JB, Dumut DC, Radzioch D, Hajdúch M. Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults. Nutrients. 2020; 12(12):3641. https://doi.org/10.3390/nu12123641

Chicago/Turabian Style

De Sanctis, Juan B., Daciana C. Dumut, Danuta Radzioch, and Marián Hajdúch. 2020. "Functionally Relevant Differences in Plasma Fatty Acid Composition and Expression of Cytotoxic and Inhibitory NK Cell Receptors between Healthy Young and Healthy Elder Adults" Nutrients 12, no. 12: 3641. https://doi.org/10.3390/nu12123641

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