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Cross-Talk between Diet-Associated Dysbiosis and Hand Osteoarthritis

1
CINTESIS, NOVA Medical School, NMS, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal
2
CHRC, CEDOC, NOVA Medical School, NMS, Universidade Nova de Lisboa, 1169-056 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3469; https://doi.org/10.3390/nu12113469
Received: 30 October 2020 / Revised: 9 November 2020 / Accepted: 9 November 2020 / Published: 12 November 2020
(This article belongs to the Special Issue Nutrition and Metabolism in Rheumatic Diseases)
Hand osteoarthritis (OA) is a degenerative joint disease which leads to pain and disability. Recent studies focus on the role of obesity and metabolic syndrome in inducing or worsening joint damage in hand OA patients, suggesting that chronic low-grade systemic inflammation may represent a possible linking factor. The gut microbiome has a crucial metabolic role which is fundamental for immune system development, among other important functions. Intestinal microbiota dysbiosis may favour metabolic syndrome and low-grade inflammation—two important components of hand OA onset and evolution. The aim of this narrative is to review the recent literature concerning the possible contribution of dysbiosis to hand OA onset and progression, and to discuss the importance of gut dysbiosis on general health and disease. View Full-Text
Keywords: diet; dysbiosis; lipopolysaccharide; hand osteoarthritis; obesity; trimethylamine-N-oxide; vitamin D diet; dysbiosis; lipopolysaccharide; hand osteoarthritis; obesity; trimethylamine-N-oxide; vitamin D
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MDPI and ACS Style

Silvestre, M.P.; Rodrigues, A.M.; Canhão, H.; Marques, C.; Teixeira, D.; Calhau, C.; Branco, J. Cross-Talk between Diet-Associated Dysbiosis and Hand Osteoarthritis. Nutrients 2020, 12, 3469. https://doi.org/10.3390/nu12113469

AMA Style

Silvestre MP, Rodrigues AM, Canhão H, Marques C, Teixeira D, Calhau C, Branco J. Cross-Talk between Diet-Associated Dysbiosis and Hand Osteoarthritis. Nutrients. 2020; 12(11):3469. https://doi.org/10.3390/nu12113469

Chicago/Turabian Style

Silvestre, Marta P., Ana M. Rodrigues, Helena Canhão, Cláudia Marques, Diana Teixeira, Conceição Calhau, and Jaime Branco. 2020. "Cross-Talk between Diet-Associated Dysbiosis and Hand Osteoarthritis" Nutrients 12, no. 11: 3469. https://doi.org/10.3390/nu12113469

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