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Open AccessArticle

Anti-Vascular Inflammatory Effect of Ethanol Extract from Securinega suffruticosa in Human Umbilical Vein Endothelial Cells

1
Hanbang Cardio-Renal Syndrome Research Center, Wonkwang University, 460, Iksan-daero, Iksan 54538, Jeonbuk, Korea
2
College of Oriental Medicine and Professional Graduate School of Oriental Medicine, Wonkwang University, 460, Iksan-daero, Iksan 54538, Jeonbuk, Korea
3
Herbal Medicine Research Division, Korea Institute of Oriental Medicine, 1672 Yuseong-daero, Yuseong-gu, Daejeon 34054, Korea
*
Authors to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3448; https://doi.org/10.3390/nu12113448
Received: 22 September 2020 / Revised: 6 November 2020 / Accepted: 7 November 2020 / Published: 10 November 2020
(This article belongs to the Section Phytochemicals and Human Health)
Securiniga suffruticosa is known as a drug that has the effect of improving the blood circulation and relaxing muscles and tendons, thereby protects and strengthen kidney and spleen. Therefore, in this study, treatment of Securiniga suffruticosa showed protective effect of inhibiting the vascular inflammation in human umbilical vein endothelial cells (HUVECs) by inducing nitric oxide (NO) production and endothelial nitric oxide synthase (eNOS) coupling pathway. In this study, Securiniga suffruticosa suppressed TNF-α (Tumor necrosis factor–α) induced protein and mRNA levels of cell adhesion molecules such as intracellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1) and Interleukin-6 (IL-6). Pretreatment of HUVEC with Securiniga suffruticosa decreased the adhesion of HL-60 cells to Ox-LDL (Oxidized Low-Density-Lipoprotein)-induced HUVEC. Moreover, Securiniga suffruticosa inhibited TNF-α induced intracellular reactive oxygen species (ROS) production. Securiniga suffruticosa also inhibited phosphorylation of IκB-α in cytoplasm and translocation of NF-κB (Nuclear factor-kappa B) p65 to the nucleus. Securiniga suffruticosa increased NO production, as well increased the phosphorylation of eNOS and Akt (protein kinase B) which are related with NO production. In addition, Securiniga suffruticosa increased the protein expression of GTPCH (Guanosine triphosphate cyclohydrolase Ⅰ) and the production of BH4 in HUVEC which are related with eNOS coupling pathway. In conclusion, Securiniga suffruticosa has a protective effect against vascular inflammation and can be a potential therapeutic agent for early atherosclerosis. View Full-Text
Keywords: vascular inflammation; Securiniga suffruticosa; HUVECs; TNF-α; adhesion molecules; NO vascular inflammation; Securiniga suffruticosa; HUVECs; TNF-α; adhesion molecules; NO
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MDPI and ACS Style

Han, B.H.; Song, C.H.; Yoon, J.J.; Kim, H.Y.; Seo, C.S.; Kang, D.G.; Lee, Y.J.; Lee, H.S. Anti-Vascular Inflammatory Effect of Ethanol Extract from Securinega suffruticosa in Human Umbilical Vein Endothelial Cells. Nutrients 2020, 12, 3448. https://doi.org/10.3390/nu12113448

AMA Style

Han BH, Song CH, Yoon JJ, Kim HY, Seo CS, Kang DG, Lee YJ, Lee HS. Anti-Vascular Inflammatory Effect of Ethanol Extract from Securinega suffruticosa in Human Umbilical Vein Endothelial Cells. Nutrients. 2020; 12(11):3448. https://doi.org/10.3390/nu12113448

Chicago/Turabian Style

Han, Byung H.; Song, Chun H.; Yoon, Jung J.; Kim, Hye Y.; Seo, Chang S.; Kang, Dae G.; Lee, Yun J.; Lee, Ho S. 2020. "Anti-Vascular Inflammatory Effect of Ethanol Extract from Securinega suffruticosa in Human Umbilical Vein Endothelial Cells" Nutrients 12, no. 11: 3448. https://doi.org/10.3390/nu12113448

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