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Correction: Tallman, D.A., et al. Dietary Patterns and Health Outcomes among African American Maintenance Hemodialysis Patients. Nutrients 2020, 12(3), 797
Article

The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet

1
School of Health Sciences, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
2
Priority Research Centre for Physical Activity and Nutrition, The University of Newcastle, Callaghan, NSW 2308, Australia
3
Centre for Asthma and Respiratory Disease, Hunter Medical Research Institute, Rankin Park, NSW 2287, Australia
4
School of Biomedical Sciences and Pharmacy, Faculty of Health and Medicine, The University of Newcastle, Callaghan, NSW 2308, Australia
5
Quadram Institute Bioscience, Norwich Research Park, Norwich NR4 7UQ, UK
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3431; https://doi.org/10.3390/nu12113431
Received: 8 October 2020 / Revised: 2 November 2020 / Accepted: 3 November 2020 / Published: 9 November 2020
(This article belongs to the Section Nutrition Methodology & Assessment)
Urinary polyphenol metabolites are potential biomarkers of dietary polyphenol intake. The current study aims to evaluate associations between total diet, vegetable and fruit polyphenol intakes with urinary polyphenol metabolite concentrations in a sample of adults prescribed a diet rich in vegetables and fruit. Thirty-four participants completed a 10-week pre-post study. Participants were asked to consume Australian recommended daily vegetable and fruit serves and attend measurement sessions at baseline and at weeks 2 and 10. Two 24-h diet recalls were collected at each time-point and polyphenol intakes were calculated using the Phenol-Explorer database. Spot urine samples, collected at each time-point, were analyzed for 15 polyphenol metabolites using liquid chromatography-mass spectroscopy. Spearman’s correlation analyzes assessed the strength of relationships between urinary and dietary polyphenols. Linear mixed models were used to investigate relationships between polyphenol excretion and intake. Total urinary polyphenols were significantly correlated with total polyphenol intakes at week 10 (rs = 0.47) and fruit polyphenols at week 2 (rs = 0.38). Hippuric acid was significantly correlated with vegetable polyphenols at baseline (rs = 0.39). Relationships were identified between individual polyphenol metabolites and vegetable and fruit polyphenols. Linear mixed model analyzes identified that for every 1 mg increase in polyphenol intakes, urinary polyphenol excretion increased by 16.3 nmol/g creatinine. Although the majority of relationships were not sufficiently strong or consistent at different time-points, promising relationships were observed between total urinary polyphenols and total polyphenol intakes, and hippuric acid and vegetable polyphenols. View Full-Text
Keywords: biomarker; urine; polyphenols; fruit; vegetables biomarker; urine; polyphenols; fruit; vegetables
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MDPI and ACS Style

Clarke, E.D.; Rollo, M.E.; Collins, C.E.; Wood, L.; Callister, R.; Philo, M.; Kroon, P.A.; Haslam, R.L. The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet. Nutrients 2020, 12, 3431. https://doi.org/10.3390/nu12113431

AMA Style

Clarke ED, Rollo ME, Collins CE, Wood L, Callister R, Philo M, Kroon PA, Haslam RL. The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet. Nutrients. 2020; 12(11):3431. https://doi.org/10.3390/nu12113431

Chicago/Turabian Style

Clarke, Erin D., Megan E. Rollo, Clare E. Collins, Lisa Wood, Robin Callister, Mark Philo, Paul A. Kroon, and Rebecca L. Haslam 2020. "The Relationship between Dietary Polyphenol Intakes and Urinary Polyphenol Concentrations in Adults Prescribed a High Vegetable and Fruit Diet" Nutrients 12, no. 11: 3431. https://doi.org/10.3390/nu12113431

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