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Cafeteria Diet and High-Fructose Rodent Models of NAFLD Differ in the Metabolism of Important PUFA and Palmitoleic Acid without Additional Influence of Sex

1
Department of Animal Nutrition and Dietetics, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
2
Laboratory for Biotechnology in Aquaculture, Division of Materials Chemistry, Ruđer Bošković Institute, Bijenička cesta 54, 10000 Zagreb, Croatia
3
Institute for Medical Research and Occupational Health, Ksaverska cesta 2, 10000 Zagreb, Croatia
4
Department of Chemistry and Biochemistry, Faculty of Veterinary Medicine, University of Zagreb, Heinzelova 55, 10000 Zagreb, Croatia
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(11), 3339; https://doi.org/10.3390/nu12113339
Received: 23 September 2020 / Revised: 26 October 2020 / Accepted: 28 October 2020 / Published: 30 October 2020
(This article belongs to the Section Nutrition and Metabolism)
The objective of this study was to evaluate the influence of high-fat (HF) and cafeteria diet (CAF) diets and sex on the metabolism of important fatty acids in the liver and perirenal fat tissue. Dietary treatments induced changes in the fatty acid profile in comparison to the untreated group, but the characteristic differences between treated groups were also observable. The HF diet induced an increase in the content of C16:1n-7 and C18:1n-7 in the liver phospholipids (PL) and triglycerides (TG) and perirenal fat tissue compared to the control and CAF diet. The CAF diet induced a more drastic decrease in both n-3 and n-6 polyunsaturated fatty acids (PUFA), including depletion of eicosapentaenoic acid (EPA). The CAF diet also increased the content of n-6 docosapentaenoic acid (DPAn-6) in the liver and decreased it in the perirenal fat. Sex also had a significant influence on the fatty acid profile, but the variables with the highest differences between the CAF and HF treatments were identical in the male and female rats. In this study, we have established that two dietary models of non-alcoholic fatty liver disease (NAFLD) led to characteristic changes in the hepatic and perirenal fat fatty acid profile, in contrast to the control diet and in comparison with each other. These differences could play an important role in the interpretation of the experimental results of nutritional studies. View Full-Text
Keywords: cafeteria diet; high-fructose diet; NAFLD; fatty acids cafeteria diet; high-fructose diet; NAFLD; fatty acids
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MDPI and ACS Style

Mašek, T.; Barišić, J.; Micek, V.; Starčević, K. Cafeteria Diet and High-Fructose Rodent Models of NAFLD Differ in the Metabolism of Important PUFA and Palmitoleic Acid without Additional Influence of Sex. Nutrients 2020, 12, 3339. https://doi.org/10.3390/nu12113339

AMA Style

Mašek T, Barišić J, Micek V, Starčević K. Cafeteria Diet and High-Fructose Rodent Models of NAFLD Differ in the Metabolism of Important PUFA and Palmitoleic Acid without Additional Influence of Sex. Nutrients. 2020; 12(11):3339. https://doi.org/10.3390/nu12113339

Chicago/Turabian Style

Mašek, Tomislav, Josip Barišić, Vedran Micek, and Kristina Starčević. 2020. "Cafeteria Diet and High-Fructose Rodent Models of NAFLD Differ in the Metabolism of Important PUFA and Palmitoleic Acid without Additional Influence of Sex" Nutrients 12, no. 11: 3339. https://doi.org/10.3390/nu12113339

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