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Microbiota, Fiber, and NAFLD: Is There Any Connection?

Endocrine and Nutrition Service, Germans Trias i Pujol Hospital and Research Institute, Universitat Autònoma de Barcelona, 08916 Badalona, Spain
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Author to whom correspondence should be addressed.
Both authors contributed equally to this work.
Both authors contributed equally to this work.
Nutrients 2020, 12(10), 3100; https://doi.org/10.3390/nu12103100
Received: 7 September 2020 / Revised: 6 October 2020 / Accepted: 9 October 2020 / Published: 12 October 2020
(This article belongs to the Special Issue The Role of Diet in Fatty Liver Disease)
Gut microbiota can contribute to the development and progression of non-alcoholic fatty liver disease (NAFLD). In fact, some specific changes of gut microbiota are observed in patients in what is called dysbiota. There has been a lot of investigation by using a variety of interventions, including diet, showing the possibility to modify components of gastrointestinal dysbiota towards healthy and multivariate microbiota to restore physiologic status. One of the main focuses has been dietary fiber (DF), in which most of its variants are prebiotics. The highest effective treatment for NAFLD is, so far, weight loss achieved by caloric restriction. DF supplementation with oligofructose facilitates weight loss, enhances the production of beneficial metabolites, decreases some pathogenic bacteria population by increasing Bifidobacteria, and has effects on intestinal barrier permeability. DF use has been associated with improvement in diverse metabolic diseases, including NAFLD, by modifying gut microbiota. Additionally, it has been shown that a higher insoluble fiber consumption (≥7.5 g/day) revealed improvements in 3 different scores of liver fibrosis. Further research is needed, but given the evidence available, it is reasonable to prescribe its consumption in early stages of NAFLD in order to prevent disease progression. View Full-Text
Keywords: NAFLD; NASH; microbiota; fiber; prebiotics; diet NAFLD; NASH; microbiota; fiber; prebiotics; diet
MDPI and ACS Style

Pérez-Montes de Oca, A.; Julián, M.T.; Ramos, A.; Puig-Domingo, M.; Alonso, N. Microbiota, Fiber, and NAFLD: Is There Any Connection? Nutrients 2020, 12, 3100. https://doi.org/10.3390/nu12103100

AMA Style

Pérez-Montes de Oca A, Julián MT, Ramos A, Puig-Domingo M, Alonso N. Microbiota, Fiber, and NAFLD: Is There Any Connection? Nutrients. 2020; 12(10):3100. https://doi.org/10.3390/nu12103100

Chicago/Turabian Style

Pérez-Montes de Oca, Alejandra; Julián, María T.; Ramos, Analía; Puig-Domingo, Manel; Alonso, Nuria. 2020. "Microbiota, Fiber, and NAFLD: Is There Any Connection?" Nutrients 12, no. 10: 3100. https://doi.org/10.3390/nu12103100

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Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

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