Next Article in Journal
In Vivo Fat Quantification: Monitoring Effects of a 6-Week Non-Energy-Restricted Ketogenic Diet in Healthy Adults Using MRI, ADP and BIA
Next Article in Special Issue
Infants’ Vitamin D Nutritional Status in the First Year of Life in Northern Taiwan
Previous Article in Journal
Association Between Diet, Physical Activity and Body Mass Index, Fat Mass Index and Bone Mineral Density of Soldiers of the Polish Air Cavalry Units
Previous Article in Special Issue
Potential Beneficial Effects of Vitamin D in Coronary Artery Disease
Open AccessReview

The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment

1
Department of Pathophysiology of Hearing and Balance System, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
2
Department of Otolaryngology, Head and Neck Surgery, and Laryngological Oncology, Ludwik Rydygier, Collegium Medicum in Bydgoszcz Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
3
Department of Pharmacology and Therapeutics, Faculty of Medicine, Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, M. Curie 9, 85-090 Bydgoszcz, Poland
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 243; https://doi.org/10.3390/nu12010243
Received: 7 November 2019 / Revised: 2 January 2020 / Accepted: 14 January 2020 / Published: 17 January 2020
(This article belongs to the Special Issue Vitamin D in Health and the Prevention and Treatment of Disease)
Some studies have suggested a link between vitamin D and headache; however, the underlying physiological mechanisms are unclear. We aimed to summarize the available evidence on the relationship between vitamin D and the various subtypes of primary headaches, including migraines and tension-type headaches. All articles concerning the association between primary headache and vitamin D published up to October 2019 were retrieved by searching clinical databases, including: EMBASE, MEDLINE, PubMed, Google scholar, and the Cochrane library. All types of studies (i.e., observational, cross-sectional, case-control, and clinical trials) were included. We identified 22 studies investigating serum vitamin D levels in association with headaches. Eight studies also evaluated the effect of vitamin D supplementation on the various headache parameters. Among them, 18 studies showed a link between serum vitamin D levels and headaches, with the strongest connection reported between serum vitamin D levels and migraine. Overall, there is not enough evidence to recommend vitamin D supplementation to all headache patients, but the current literature indicates that it may be beneficial in some patients suffering headaches, mainly migraineurs, to reduce the frequency of headaches, especially in those with vitamin D deficiency. View Full-Text
Keywords: cholecalciferol; headache; migraine; tension-type headache; cluster headache; pain; vitamin D; 25-hydroxy-vitamin D cholecalciferol; headache; migraine; tension-type headache; cluster headache; pain; vitamin D; 25-hydroxy-vitamin D
Show Figures

Figure 1

MDPI and ACS Style

Nowaczewska, M.; Wiciński, M.; Osiński, S.; Kaźmierczak, H. The Role of Vitamin D in Primary Headache–from Potential Mechanism to Treatment. Nutrients 2020, 12, 243.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop