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Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial

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Kubota Children’s Clinic, 2-6-18 Katsuyamakita Ikunoku, Osaka 544-0033, Japan
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Department of Public Health, Osaka City University Graduate School of Medicine, 1-4-3 Asahimachi Abenoku, Osaka 545-0051, Japan
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Tomimoto Pediatric Clinic, 6-6-20 Minatotakadai, Hachinohe 031-0823, Japan
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Kanazaki Children’s Clinic, 3323 Dotocho Nakaku, Sakai 599-8234, Japan
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Tsukiyama Child Care Clinic, 484 Akizuki, Wakayama 640-8322, Japan
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Sotobo Children’s Clinic, 1880-4 Izumi Misakicho, Isumi 299-4503, Japan
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Department of Microbiology, Kindai University Faculty of Medicine, 377-2 Ohnohigashi, Osakasayama 589-8511, Japan
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KidZ Health Castle, UZ Brussel, Vrije Universiteit Brussel, 1090 Brussels, Belgium
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Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 225; https://doi.org/10.3390/nu12010225
Received: 2 December 2019 / Revised: 10 January 2020 / Accepted: 12 January 2020 / Published: 15 January 2020
Objective: Chronic functional constipation is a frequent condition. The aim of the study was to evaluate the efficacy of the probiotic Lactobacillus (L.) reuteri DSM 17938 and magnesium oxide (MgO) for relieving chronic functional constipation in children. Study design: A prospective, double-blind, placebo-controlled, randomized, and parallel-group trial was conducted in five pediatric outpatient clinics in Japan. Sixty patients who were more than six months old and under six years of age with a diagnosis of functional constipation according to Rome IV criteria were randomly divided into three groups: group A (n = 20) received L. reuteri DSM 17938 and lactose hydrate as a placebo of MgO; group B (n = 19) received L. reuteri DSM 17938 and MgO; and group C (n = 21) received a placebo of L. reuteri DSM 17938 and MgO. Results: All three groups exhibited significant improvement in defecation frequency in the fourth week compared with the baseline condition (group A: p < 0.05; group B: p < 0.05; group C: p < 0.05). The MgO group and combination group showed a significant decrease in stool consistency, but the L. reuteri DSM 17938 group did not (group A: p = 0.079; group B: p < 0.05; group C: p < 0.05). MgO significantly suppressed the presence of the genus Dialister. Defecation frequency negatively correlated with the frequency of Clostridiales-belonging bacteria among the gut microbiome. Conclusions: L. rueteri DSM 17938 and MgO were both effective in the management of functional constipation in young children. MgO caused an imbalance in the gastrointestinal microbiome, which was not the case in the probiotic group. View Full-Text
Keywords: constipation; Dialister; functional gastrointestinal disorder; Lactobacillus; magnesium oxide; microbiome; Bristol stool scale constipation; Dialister; functional gastrointestinal disorder; Lactobacillus; magnesium oxide; microbiome; Bristol stool scale
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Kubota, M.; Ito, K.; Tomimoto, K.; Kanazaki, M.; Tsukiyama, K.; Kubota, A.; Kuroki, H.; Fujita, M.; Vandenplas, Y. Lactobacillus reuteri DSM 17938 and Magnesium Oxide in Children with Functional Chronic Constipation: A Double-Blind and Randomized Clinical Trial. Nutrients 2020, 12, 225.

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