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Open AccessArticle

Role of Resveratrol in Transmitochondrial AMD RPE Cells

1
Department of Ophthalmology, Gavin Herbert Eye Institute, University of California Irvine, Irvine, CA 92697, USA
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Cedars-Sinai Medical Center, Los Angeles, CA 92697, USA
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Department of Pathology and Laboratory Medicine, University of California Irvine, Irvine, CA 92697, USA
*
Author to whom correspondence should be addressed.
Nutrients 2020, 12(1), 159; https://doi.org/10.3390/nu12010159
Received: 12 November 2019 / Revised: 2 December 2019 / Accepted: 27 December 2019 / Published: 6 January 2020
Resveratrol is a phytoalexin, stilbenoid compound with antioxidant properties attributable to its bioactive trans-resveratrol content. This study characterized the effects of over-the-counter (OTC) resveratrol nutritional supplements and a HPLC-purified resveratrol formulation, in human transmitochondrial age-related macular degeneration (AMD) retinal pigment epithelial (RPE) patient cell lines. These cell lines, which were created by fusing blood platelets obtained from dry and wet AMD patients with mitochondria-deficient (Rho0) ARPE-19 cells, had identical nuclei (derived from ARPE-19 cells) but different mitochondria that were derived from AMD patients. After resveratrol treatment, the levels of cell viability and reactive oxygen species production were measured. Results demonstrated that treatment with different resveratrol formulations improved cell viability and decreased reactive oxygen species generation in each AMD patient cell line. Although further studies are required to establish the cytoprotective potential of resveratrol under different physiological conditions, this novel study established the positive effects of OTC resveratrol supplements in macular degeneration patient cybrid cell lines in vitro. View Full-Text
Keywords: resveratrol; nutraceutical; stilbenoid; phytoalexin; age-related macular degeneration; AMD; macular degeneration; retina; retinal pigment epithelial cells; RPE; cybrids; over-the-counter nutritional supplements resveratrol; nutraceutical; stilbenoid; phytoalexin; age-related macular degeneration; AMD; macular degeneration; retina; retinal pigment epithelial cells; RPE; cybrids; over-the-counter nutritional supplements
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Nashine, S.; Nesburn, A.B.; Kuppermann, B.D.; Kenney, M.C. Role of Resveratrol in Transmitochondrial AMD RPE Cells. Nutrients 2020, 12, 159.

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