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Open AccessArticle

Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study

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IRCCS Mondino Foundation, 27100 Pavia, Italy
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Department of Public Health, Experimental and Forensic Medicine, Unit of Human and Clinical Nutrition, University of Pavia, 27100 Pavia, Italy
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Endocrinology and Nutrition Unit, Azienda di Servizialla Persona ‘‘Istituto Santa Margherita’’, University of Pavia, 27100 Pavia, Italy
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General Management, Azienda di Servizialla Persona Istituto Santa Margherita, 27100 Pavia, Italy
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Clinical & Pre-clinical Development, Gnosis SpA, 20121 Milan, Italy
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SP Diabetic Outpatient Clinic, ASST Monza, 20900 Monza, Italy
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Department of Biology, College of Science, University of Bahrain, Sakhir Campus P. O. Box 32038, Bahrain
*
Authors to whom correspondence should be addressed.
Nutrients 2019, 11(9), 2027; https://doi.org/10.3390/nu11092027
Received: 11 July 2019 / Revised: 9 August 2019 / Accepted: 14 August 2019 / Published: 29 August 2019
Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. This study aims to investigate the anti-inflammatory effects, anti-pain and ability-enhancement of a short-term supplementation with non-animal CS in overweight subjects with OA. In a randomized, double-blind, placebo-controlled pilot study, 60 overweight adults with symptomatic OA were allocated to consume 600 mg of non-animal CS (n = 30) or a placebo (n = 30) daily for 12 consecutive weeks. The assessment of knee-pain, quality of life, related inflammation markers and body composition was performed at 0, 4 and 12 weeks. The Tegner Lysholm Knee Scoring (TLKS) scale of the experimental group showed a statistically significant increase (+10.64 points; confidence interval (95% confidence interval (CI) 5.57; 15.70; p < 0.01), while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score decreased (−12.24 points; CI 95% −16.01; −8.38; p < 0.01). The results also showed a decrease in the C-reactive protein (CRP) level (−0.14 mg/dL, CI 95% −0.26; −0.04; p < 0.01) and erythrocyte sedimentation rate (ESR) level (−5.01 mm/h, CI 95% −9.18; −0.84, p < 0.01) as well as the visual analogue scale (VAS) score in both knees. In conclusion, this pilot study demonstrates the effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers. View Full-Text
Keywords: non-animal chondroitin sulfate; knee osteoarthritis; pain; inflammation; overweight; obesity non-animal chondroitin sulfate; knee osteoarthritis; pain; inflammation; overweight; obesity
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MDPI and ACS Style

Rondanelli, M.; Braschi, V.; Gasparri, C.; Nichetti, M.; Faliva, M.A.; Peroni, G.; Naso, M.; Iannello, G.; Spadaccini, D.; Miraglia, N.; Putignano, P.; Alalwan, T.A.; Perna, S. Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients 2019, 11, 2027. https://doi.org/10.3390/nu11092027

AMA Style

Rondanelli M, Braschi V, Gasparri C, Nichetti M, Faliva MA, Peroni G, Naso M, Iannello G, Spadaccini D, Miraglia N, Putignano P, Alalwan TA, Perna S. Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study. Nutrients. 2019; 11(9):2027. https://doi.org/10.3390/nu11092027

Chicago/Turabian Style

Rondanelli, Mariangela; Braschi, Valentina; Gasparri, Clara; Nichetti, Mara; Faliva, Milena A.; Peroni, Gabriella; Naso, Maurizio; Iannello, Giancarlo; Spadaccini, Daniele; Miraglia, Niccolò; Putignano, Pietro; Alalwan, Tariq A.; Perna, Simone. 2019. "Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study" Nutrients 11, no. 9: 2027. https://doi.org/10.3390/nu11092027

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