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Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition

1
School of Life and Environmental Sciences, Faculty of Science, The University of Sydney, Sydney 2006, Australia
2
Charles Perkins Centre, Camperdown, The University of Sydney, Sydney 2006, Australia
3
Sydney Medical School, Faculty of Health and Medicine, The University of Sydney, Sydney 2006, Australia
4
Heart Research Institute, The University of Sydney, Sydney 2006, Australia
5
ARC Centre of Excellence in Population Ageing Research (CEPAR), Kensington 2033, Australia
6
Concord Clinical School, Faculty of Health and Medicine, The University of Sydney, Concord 2139, Australia
7
ANZAC Research Institute, The University of Sydney, Concord 2139, Australia
8
School of Public Health, University of Sydney, Sydney 2006, Australia
9
Ageing and Alzheimers Institute, Concord Hospital, University of Sydney, Concord 2139, Australia
*
Authors to whom correspondence should be addressed.
These two authors contribute equally to this paper.
Nutrients 2019, 11(8), 1882; https://doi.org/10.3390/nu11081882
Received: 22 July 2019 / Revised: 6 August 2019 / Accepted: 6 August 2019 / Published: 13 August 2019
(This article belongs to the Special Issue Amino Acid Nutrition and Metabolism in Health and Disease)
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Abstract

Protein and branched-chain amino acid (BCAA) intake are associated with changes in circulating BCAAs and influence metabolic health in humans and rodents. However, the relationship between BCAAs and body composition in both species is unclear, with many studies questioning the translatability of preclinical findings to humans. Here, we assessed and directly compared the relationship between circulating BCAAs, body composition, and intake in older mice and men. Body weight and body fat were positively associated with circulating BCAA levels in both mouse and human, which remained significant after adjustments for age, physical activity, number of morbidities, smoking status, and source of income in the human cohort. Macronutrient intakes were similarly associated with circulating BCAA levels; however, the relationship between protein intake and BCAAs were more pronounced in the mice. These findings indicate that the relationship between circulating BCAAs, body composition, and intakes are comparable in both species, suggesting that the mouse is an effective model for examining the effects of BCAAs on body composition in older humans. View Full-Text
Keywords: branched-chain amino acids; body composition; ageing; mice; humans branched-chain amino acids; body composition; ageing; mice; humans
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Ribeiro, R.V.; Solon-Biet, S.M.; Pulpitel, T.; Senior, A.M.; Cogger, V.C.; Clark, X.; O’Sullivan, J.; Koay, Y.C.; Hirani, V.; Blyth, F.M.; Seibel, M.J.; Waite, L.M.; Naganathan, V.; Cumming, R.G.; Handelsman, D.J.; Simpson, S.J.; Couteur, D.G.L. Of Older Mice and Men: Branched-Chain Amino Acids and Body Composition. Nutrients 2019, 11, 1882.

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