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The Modern Western Diet Rich in Advanced Glycation End-Products (AGEs): An Overview of Its Impact on Obesity and Early Progression of Renal Pathology

1
Urological Research Institute, Division of Experimental Oncology, IRCCS San Raffaele Scientific Institute, 20132 Milano, Italy
2
Università Vita-Salute San Raffaele, 20132 Milano, Italy
3
PHYTOLAB (Pharmaceutical, Cosmetic, Food supplement Technology and Analysis)-DiSIA, University of Florence, 50019 Sesto Fiorentino (Florence), Italy
4
Universidad de La Laguna, Dep de Medicina Interna, ITB, Instituto de Tecnologías Biomédicas, 38320 La Laguna, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(8), 1748; https://doi.org/10.3390/nu11081748
Received: 31 May 2019 / Revised: 15 July 2019 / Accepted: 25 July 2019 / Published: 30 July 2019
(This article belongs to the Special Issue Preventive Nutrition)
Advanced glycation end-products (AGEs) are an assorted group of molecules formed through covalent bonds between a reduced sugar and a free amino group of proteins, lipids, and nucleic acids. Glycation alters their structure and function, leading to impaired cell function. They can be originated by physiological processes, when not counterbalanced by detoxification mechanisms, or derive from exogenous sources such as food, cigarette smoke, and air pollution. Their accumulation increases inflammation and oxidative stress through the activation of various mechanisms mainly triggered by binding to their receptors (RAGE). So far, the pathogenic role of AGEs has been evidenced in inflammatory and chronic diseases such as chronic kidney disease, cardiovascular disease, and diabetic nephropathy. This review focuses on the AGE-induced kidney damage, by describing the molecular players involved and investigating its link to the excess of body weight and visceral fat, hallmarks of obesity. Research regarding interventions to reduce AGE accumulation has been of great interest and a nutraceutical approach that would help fighting chronic diseases could be a very useful tool for patients’ everyday lives. View Full-Text
Keywords: advanced glycation end-products (AGEs); diet; renal disease; obesity; carboximethyl-lysine (CML) advanced glycation end-products (AGEs); diet; renal disease; obesity; carboximethyl-lysine (CML)
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MDPI and ACS Style

Bettiga, A.; Fiorio, F.; Di Marco, F.; Trevisani, F.; Romani, A.; Porrini, E.; Salonia, A.; Montorsi, F.; Vago, R. The Modern Western Diet Rich in Advanced Glycation End-Products (AGEs): An Overview of Its Impact on Obesity and Early Progression of Renal Pathology. Nutrients 2019, 11, 1748. https://doi.org/10.3390/nu11081748

AMA Style

Bettiga A, Fiorio F, Di Marco F, Trevisani F, Romani A, Porrini E, Salonia A, Montorsi F, Vago R. The Modern Western Diet Rich in Advanced Glycation End-Products (AGEs): An Overview of Its Impact on Obesity and Early Progression of Renal Pathology. Nutrients. 2019; 11(8):1748. https://doi.org/10.3390/nu11081748

Chicago/Turabian Style

Bettiga, Arianna; Fiorio, Francesco; Di Marco, Federico; Trevisani, Francesco; Romani, Annalisa; Porrini, Esteban; Salonia, Andrea; Montorsi, Francesco; Vago, Riccardo. 2019. "The Modern Western Diet Rich in Advanced Glycation End-Products (AGEs): An Overview of Its Impact on Obesity and Early Progression of Renal Pathology" Nutrients 11, no. 8: 1748. https://doi.org/10.3390/nu11081748

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