Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

Department of Biochemistry and Molecular Biology II, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18100 Armilla, Granada, Spain

Department of Physiology, Phaculty of Medicine, University of Granada, Parque Tecnológico de la Salud, Avenida del Conocimiento s/n, 18100 Armilla, Granada, Spain

Department of Pharmacology, Phaculty of Pharmacy, University of Granada, Campus Cartuja s/n, 180710 Armilla, Granada, Spain

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Instituto para la Calidad y Seguridad Alimentaria S.L. (ICSA)-TECNOFOOD I+D SOLUCIONES S.L., Avenida de la Hispanidad 17, 18320 Santa Fe, Granada, Spain

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Laboratorio CM Europa S.L., Polígono Industrial “Cañada de la Fuente”, Carretera Fuensanta, s/n, 23600 Martos, Jaén, Spain

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Vegetable By-Products of Mediterráneo, SL, Cl Isla Menor CEP Jose Maria Blanco SN, 41010 Seville, Spain

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Fat Institute: Department of Food Phytochemistry Campus of the Pablo de Olavide University, Building 46 Ctra. De Utrera, km. 1, 41013 Seville, Spain

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Department of Analytical Chemistry, Faculty of Science, University of Granada, Ave. Fuentenueva s/n, 18071 Granada, Spain

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Cardiovascular Risk and Nutrition Research Group, Hospital del Mar Medical Research Institute (IMIM), Dr. Aiguader 88, 08003 Barcelona, Spain

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Spanish Biomedical Research Networking Centre, Physiopathology of Obesity and Nutrition (CIBEROBN), Instituto de Salud Carlos III. Monforte de Lemos 3-5, 28029 Madrid, Spain

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NUPROAS Handelsbolag, Nackã, Sweden, NUPROAS HB, Spanish Office: Apartado de Correos 93, 17242 Girona, Spain

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Department of Physiology, Institute of Nutrition and Food Technology “José Mataix”, Biomedical Research Center, University of Granada, Health Technology Park, Avd of Conocimiento s/n, 18100 Armilla, Granada, Spain

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Biosanitary Research Institute of Granada, 18014 Granada, Spain

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Nutrients 2019, 11(8), 1728; https://doi.org/10.3390/nu11081728

Received: 25 June 2019 / Revised: 22 July 2019 / Accepted: 24 July 2019 / Published: 26 July 2019

(This article belongs to the Special Issue Dietary Lipids and Human Health)

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Abstract

Olive oil and its derivatives have been described to exert beneficial effects on hypertensive states and cardiovascular disease prevention. We studied the effects of chronic consumption of extra virgin olive oil (EVOO), enriched in bioactive compounds from olive fruit and leaves, on blood pressure, endothelial function, oxidative and inflammatory status, and circulating cholesterol levels, in spontaneously hypertensive rats (SHR). Thirty SHR were randomly assigned to three groups: a control untreated SHR group, an SHR group (1 mL/rat/day) of a control olive oil (17.6 mg/kg of phenolic compounds), and an SHR group (1 mL/rat/day) of the enriched EVOO (750 mg/kg of phenolic compounds) for eight weeks. Ten Wistar Kyoto rats (WKY) were included as healthy controls. Long-term administration of the enriched EVOO decreased systolic blood pressure and cardiac hypertrophy, and improved the ex vivo aortic endothelial dysfunction measured in SHR. Moreover, enriched oil supplementation reduced the plasma levels of Angiotensin II and total cholesterol, and the urinary levels of endothelin-1 and oxidative stress biomarkers, while pro-inflammatory cytokines were unaffected. In conclusion, sustained treatment with EVOO, enriched in bioactive compounds from the olive fruit and leaves, may be an effective tool for reducing blood pressure and cholesterol levels alone or in combination with pharmacological anti-hypertensive treatment. View Full-Text

Keywords: extra virgin olive oil; phenolic compounds; hypertension; endothelial function

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MDPI and ACS Style

Vazquez, A.; Sanchez-Rodriguez, E.; Vargas, F.; Montoro-Molina, S.; Romero, M.; Espejo-Calvo, J.A.; Vilchez, P.; Jaramillo, S.; Olmo-García, L.; Carrasco-Pancorbo, A.; de la Torre, R.; Fito, M.; Covas, M.-I.; Martínez de Victoria, E.; Mesa, M.D. Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats. Nutrients 2019, 11, 1728. https://doi.org/10.3390/nu11081728

AMA Style

Vazquez A, Sanchez-Rodriguez E, Vargas F, Montoro-Molina S, Romero M, Espejo-Calvo JA, Vilchez P, Jaramillo S, Olmo-García L, Carrasco-Pancorbo A, de la Torre R, Fito M, Covas M-I, Martínez de Victoria E, Mesa MD. Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats. Nutrients. 2019; 11(8):1728. https://doi.org/10.3390/nu11081728

Chicago/Turabian Style

Vazquez, Alejandra, Estefania Sanchez-Rodriguez, Félix Vargas, Sebastián Montoro-Molina, Miguel Romero, Juan A. Espejo-Calvo, Pedro Vilchez, Sara Jaramillo, Lucía Olmo-García, Alegría Carrasco-Pancorbo, Rafael de la Torre, Montserrat Fito, María-Isabel Covas, Emilio Martínez de Victoria, and Maria D. Mesa. 2019. "Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats" Nutrients 11, no. 8: 1728. https://doi.org/10.3390/nu11081728

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Cardioprotective Effect of a Virgin Olive Oil Enriched with Bioactive Compounds in Spontaneously Hypertensive Rats

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