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Open AccessArticle

Allelic Variation in Taste Genes Is Associated with Taste and Diet Preferences and Dental Caries

1
Department of Odontology/Section of Pedodontics, Umeå University, 901 87 Umeå, Sweden
2
Department of Odontology/Section of Cariology, Umeå University, 901 87 Umeå, Sweden
3
Medical Research Council Integrative Epidemiology Unit, Department of Population Health Sciences, Bristol Medical School, University of Bristol, Bristol BS8 2BN, UK
4
Bristol Dental School, University of Bristol, Bristol BS1 2LY, UK
*
Author to whom correspondence should be addressed.
These authors contributed equally.
Nutrients 2019, 11(7), 1491; https://doi.org/10.3390/nu11071491
Received: 12 June 2019 / Revised: 27 June 2019 / Accepted: 28 June 2019 / Published: 29 June 2019
Taste and diet preferences are complex and influenced by both environmental and host traits while affecting both food selection and associated health outcomes. The present study genotyped 94 single nucleotide polymorphisms (SNPs) in previously reported taste and food intake related genes and assessed associations with taste threshold (TT) and preferred intensity (PT) of sweet, sour and bitter, food preferences, habitual diet intake, and caries status in healthy young Swedish men and women (n = 127). Polymorphisms in the GNAT3, SLC2A4, TAS1R1 and TAS1R2 genes were associated with variation in TT and PT for sweet taste as well as sweet food intake. Increasing PT for sweet was associated with increasing preference and intake of sugary foods. Similarly, increasing TT for sour was associated with increasing intake of sour foods, whereas the associations between food preference/intake and TT/PT for bitter was weak in this study group. Finally, allelic variation in the GNAT3, SLC2A2, SLC2A4, TAS1R1 and TAS1R2 genes was associated with caries status, whereas TT, PT and food preferences were not. It was concluded that variations in taste receptor, glucose transporter and gustducin encoding genes are related to taste perception, food preference and intake as well as the sugar-dependent caries disease. View Full-Text
Keywords: taste perception; taste preference; taste genes; diet preference; diet selection; caries taste perception; taste preference; taste genes; diet preference; diet selection; caries
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Eriksson, L.; Esberg, A.; Haworth, S.; Holgerson, P.L.; Johansson, I. Allelic Variation in Taste Genes Is Associated with Taste and Diet Preferences and Dental Caries. Nutrients 2019, 11, 1491.

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