Next Article in Journal
Adaptation and Validation of Alternative Healthy Eating Index in Hemodialysis Patients (AHEI-HD) and Its Association with all-Cause Mortality: A Multi-Center Follow-Up Study
Previous Article in Journal
Nutritional Interventions to Improve Clinical Outcomes in Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
Previous Article in Special Issue
Association between Adherence to the Antioxidant-Rich Mediterranean Diet and Sensory Processing Profile in School-Aged Children: The Spanish Cross-Sectional InProS Project
Article Menu

Article Menu


Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)

Oncology Data Analytics Program (ODAP), Catalan Institute of Oncology (ICO), L’Hospitalet del Llobregat, 08908 Barcelona, Spain
ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL), L’Hospitalet de Llobregat, 08908 Barcelona, Spain
Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), 28029 Madrid, Spain
Instituto de Salud Global de Barcelona (ISGlobal), 08036 Barcelona, Spain
Instituto de Investigación Sanitaria Illes Balears (IdISBa), 07120 Palma de Mallorca, Spain
CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN), 28029 Madrid, Spain
Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra (UPF), 08002 Barcelona, Spain
Genetic and Molecular Epidemiology Group, Spanish National Cancer Research Center (CNIO), 28029 Madrid, Spain
Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), 28029 Madrid, Spain
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA
Department of Nutrition, Connecting Health Innovations LLC (CHI), Columbia, SC 29201, USA
Department of Medicine, University of Oviedo, 33006 Oviedo, Spain
IMIM (Hospital del Mar Medical Research Institute), 08003 Barcelona, Spain
Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, 08007 Barcelona, Spain
Genetics and Cancer Prevention Group, Epidemiology Unit and Girona Cancer Registry, Descriptive Epidemiology, IdIbGi, Catalan Institute of Oncology, 17007 Girona, Spain
Public Health Division of Gipuzkoa, 20003 San Sebastian, Spain
Biodonostia Research Institute, 20014 San Sebastian, Spain
Department of Preventive Medicine and Public Health, School of Medicine, University of Granada, 18016 Granada, Spain
Instituto de Investigación Biosanitaria de Granada ibs.GRANADA, 18014 Granada, Spain
Centro de Investigación en Recursos Naturales, Salud y Medio Ambiente (RENSMA), Universidad de Huelva, 21071Huelva, Spain
The Research Group in Gene - Environment and Health Interactions (GIIGAS) / Institut of Biomedicine (IBIOMED), Universidad de León, 24071 León, Spain
Faculty of Health Sciences, Department of Biomedical Sciences, Area of Preventive Medicine and Public Health, Universidad de León, 24071 León, Spain
Navarra Public Health Institute, 31003 Pamplona, Spain
Navarra Institute for Health Research (IdiSNA), 31003 Pamplona, Spain
REDISSEC Red de Investigación en Servicios de Salud en Enfermedades Crónicas, 28029 Madrid, Spain
Cancer & Environmental Epidemiology Unit, Department of Epidemiology of Chronic Diseases, National Centre for Epidemiology, Carlos III Institute of Health, 28029 Madrid, Spain
Department of Health of Madrid, Cancer Epidemiology Section, Public Health Division, 28029 Madrid, Spain
Department of Surgery and Medical and Social Sciences. Alcalá de Henares University, 28801 Alcalá de Henares, Madrid, Spain
Department of Epidemiology, Murcia Regional Health Council, IMIB-Arrixaca, 30008 Murcia, Spain
Preventive Medicine, Universidad de Cantabria—IDIVAL, 39011 Santander, Spain
Cancer and Public Health Area, FISABIO—Public Health; 46020 Valencia, Spain
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1406;
Received: 2 May 2019 / Revised: 14 June 2019 / Accepted: 19 June 2019 / Published: 21 June 2019
(This article belongs to the Special Issue Dietary Antioxidants and Human Health)
Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent. View Full-Text
Keywords: colorectal cancer; breast cancer; diet; dietary inflammatory index; antioxidants; NEAC; case-control study; MCC-Spain colorectal cancer; breast cancer; diet; dietary inflammatory index; antioxidants; NEAC; case-control study; MCC-Spain
Show Figures

Figure 1

MDPI and ACS Style

Obón-Santacana, M.; Romaguera, D.; Gracia-Lavedan, E.; Molinuevo, A.; Molina-Montes, E.; Shivappa, N.; Hebert, J.R.; Tardón, A.; Castaño-Vinyals, G.; Moratalla, F.; Guinó, E.; Marcos-Gragera, R.; Azpiri, M.; Gil, L.; Olmedo-Requena, R.; Lozano-Lorca, M.; Alguacil, J.; Fernández-Villa, T.; Martín, V.; Molina, A.J.; Ederra, M.; Moreno-Iribas, C.; Perez, B.; Aragonés, N.; Castello, A.; Huerta, J.M.; Dierssen-Sotos, T.; Gómez-Acebo, I.; Molina-Barceló, A.; Pollán, M.; Kogevinas, M.; Moreno, V.; Amiano, P. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients 2019, 11, 1406.

AMA Style

Obón-Santacana M, Romaguera D, Gracia-Lavedan E, Molinuevo A, Molina-Montes E, Shivappa N, Hebert JR, Tardón A, Castaño-Vinyals G, Moratalla F, Guinó E, Marcos-Gragera R, Azpiri M, Gil L, Olmedo-Requena R, Lozano-Lorca M, Alguacil J, Fernández-Villa T, Martín V, Molina AJ, Ederra M, Moreno-Iribas C, Perez B, Aragonés N, Castello A, Huerta JM, Dierssen-Sotos T, Gómez-Acebo I, Molina-Barceló A, Pollán M, Kogevinas M, Moreno V, Amiano P. Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study). Nutrients. 2019; 11(6):1406.

Chicago/Turabian Style

Obón-Santacana, Mireia, Dora Romaguera, Esther Gracia-Lavedan, Amaia Molinuevo, Esther Molina-Montes, Nitin Shivappa, James R. Hebert, Adonina Tardón, Gemma Castaño-Vinyals, Ferran Moratalla, Elisabet Guinó, Rafael Marcos-Gragera, Mikel Azpiri, Leire Gil, Rocío Olmedo-Requena, Macarena Lozano-Lorca, Juan Alguacil, Tania Fernández-Villa, Vicente Martín, Antonio J. Molina, María Ederra, Conchi Moreno-Iribas, Beatriz Perez, Nuria Aragonés, Adela Castello, José M. Huerta, Trinidad Dierssen-Sotos, Inés Gómez-Acebo, Ana Molina-Barceló, Marina Pollán, Manolis Kogevinas, Victor Moreno, and Pilar Amiano. 2019. "Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)" Nutrients 11, no. 6: 1406.

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

Back to TopTop