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Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease

by 1,2,*, 1,2 and 3,4
1
Division of Medical Oncology, Department of Internal Medicine, The Ohio State University, Columbus, OH 43210, USA
2
Comprehensive Cancer Center, The Ohio State University, Columbus, OH 43210, USA
3
Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University, Columbus, OH 43210, USA
4
Inflammatory Bowel Disease Center, Wexner Medical Center, The Ohio State University, Columbus, OH 43210, USA
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1261; https://doi.org/10.3390/nu11061261
Received: 18 March 2019 / Revised: 24 May 2019 / Accepted: 27 May 2019 / Published: 3 June 2019
(This article belongs to the Special Issue Nutrition in Inflammatory Bowel Disease (IBD))
Colorectal cancer (CRC) remains the third most common cause of cancer-related death in the United States and the fourth globally with a rising incidence. Inflammatory bowel disease (IBD) is a chronic immunologically mediated disease that imposes a significant associated health burden, including the increased risk for colonic dysplasia and CRC. Carcinogenesis has been attributed to chronic inflammation and associated with oxidative stress, genomic instability, and immune effectors as well as the cytokine dysregulation and activation of the nuclear factor kappa B (NFκB) signaling pathway. Current anti-inflammation therapies used for IBD treatment have shown limited effects on CRC chemoprevention, and their long-term toxicity has limited their clinical application. However, natural food-based prevention approaches may offer significant cancer prevention effects with very low toxicity profiles. In particular, in preclinical and clinical pilot studies, strawberry and black raspberry have been widely selected as food-based interventions because of their potent preventive activities. In this review, we summarize the roles of strawberry, black raspberry, and their polyphenol components on CRC chemoprevention in IBD. View Full-Text
Keywords: colorectal cancer; inflammatory bowel disease; colorectal cancer; dysplasia; berries; chemoprevention colorectal cancer; inflammatory bowel disease; colorectal cancer; dysplasia; berries; chemoprevention
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MDPI and ACS Style

Chen, T.; Shi, N.; Afzali, A. Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease. Nutrients 2019, 11, 1261. https://doi.org/10.3390/nu11061261

AMA Style

Chen T, Shi N, Afzali A. Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease. Nutrients. 2019; 11(6):1261. https://doi.org/10.3390/nu11061261

Chicago/Turabian Style

Chen, Tong, Ni Shi, and Anita Afzali. 2019. "Chemopreventive Effects of Strawberry and Black Raspberry on Colorectal Cancer in Inflammatory Bowel Disease" Nutrients 11, no. 6: 1261. https://doi.org/10.3390/nu11061261

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