Next Article in Journal
The Relationship between Whole Grain Intake and Body Weight: Results of Meta-Analyses of Observational Studies and Randomized Controlled Trials
Previous Article in Journal
Bone Health, Body Composition, and Vitamin D Status of Black Preadolescent Children in South Africa
Due to scheduled maintenance work on our core network, there may be short service disruptions on this website between 16:00 and 16:30 CEST on September 25th.
Communication

High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice

1
School of Sports Sciences and Physical Education, Ningbo University, Ningbo 315211, China
2
Institute for Clinical Exercise & Health Science, University of the West of Scotland, Lanarkshire, Scotland G72 OLH, UK
3
School of Marine Sciences, Ningbo University, Ningbo 315211, China
4
Sport and Exercise Sciences Research Institute, Ulster University, Newtownabbey BT37 0QB, UK
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(6), 1244; https://doi.org/10.3390/nu11061244
Received: 18 May 2019 / Revised: 28 May 2019 / Accepted: 29 May 2019 / Published: 31 May 2019
Exercise-induced reactive oxygen and nitrogen species are increasingly considered as beneficial health promotion. Astaxanthin (ASX) has been recognized as a potent antioxidant suitable for human ingestion. We investigated whether ASX administration suppressed antioxidant enzyme activity in moderate-intensity exercise. Seven-week-old male C57BL/6 mice (n = 8/group) were treated with ASX (5, 15, and 30 mg/kg BW) combined with 45 min/day moderate-intensity swimming training for four weeks. Results showed that the mice administrated with 15 and 30 mg/kg of ASX decreased glutathione peroxidase, catalase, malondialdehyde, and creatine kinase levels in plasma or muscle, compared with the swimming control group. Beyond that, these two (15 and 30 mg/kg BW) dosages of ASX downregulated gastrocnemius muscle erythroid 2p45 (NF-E2)-related factor 2 (Nrf2). Meanwhile, mRNA of Nrf2 and Nrf2-dependent enzymes in mice heart were also downregulated in the ASX-treated groups. However, the mice treated with 15 or 30 mg/kg ASX had increased constitutive nitric oxidase synthase and superoxide dismutase activity, compared with the swimming and sedentary control groups. Our findings indicate that high-dose administration of astaxanthin can blunt antioxidant enzyme activity and downregulate transcription of Nrf2 and Nrf2-dependent enzymes along with attenuating plasma and muscle MDA. View Full-Text
Keywords: astaxanthin; antioxidant; oxidative stress; chronic exercise; physical adaption astaxanthin; antioxidant; oxidative stress; chronic exercise; physical adaption
Show Figures

Figure 1

MDPI and ACS Style

Zhou, Y.; Baker, J.S.; Chen, X.; Wang, Y.; Chen, H.; Davison, G.W.; Yan, X. High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice. Nutrients 2019, 11, 1244. https://doi.org/10.3390/nu11061244

AMA Style

Zhou Y, Baker JS, Chen X, Wang Y, Chen H, Davison GW, Yan X. High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice. Nutrients. 2019; 11(6):1244. https://doi.org/10.3390/nu11061244

Chicago/Turabian Style

Zhou, Yingsong, Julien S. Baker, Xiaoping Chen, Yajun Wang, Haimin Chen, Gareth W. Davison, and Xiaojun Yan. 2019. "High-Dose Astaxanthin Supplementation Suppresses Antioxidant Enzyme Activity during Moderate-Intensity Swimming Training in Mice" Nutrients 11, no. 6: 1244. https://doi.org/10.3390/nu11061244

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop