Next Article in Journal
Relation between Dietary Habits, Physical Activity, and Anthropometric and Vascular Parameters in Children Attending the Primary School in the Verona South District
Previous Article in Journal
Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin
Article Menu

Export Article

Open AccessArticle

Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats

1
EA 2160 MMS, Mer Molécules Santé, IUML FR 3473 CNRS, UFR Sciences et Techniques, 72085 Le Mans, CEDEX 9 and Institut Universitaire Technologique, Le Mans Université, 53020 Laval, CEDEX 9, France
2
National Research Council, Department of Biology, Agriculture and Food Sciences, Tree and Timber Institute, 50019 Sesto Fiorentino (Florence), Italy
3
EA 2160 MMS, Mer Molécules Santé, IUML FR 3473 CNRS, UFR Pharmacie, Université de Nantes, 44035 Nantes, CEDEX 1, France
4
UMR 1280 PhAN, Physiopathologie des Adaptations Nutritionnelles, CHU Hôtel Dieu, Université de Nantes, 44093 Nantes, CEDEX 1, France
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1069; https://doi.org/10.3390/nu11051069
Received: 11 April 2019 / Revised: 3 May 2019 / Accepted: 10 May 2019 / Published: 14 May 2019
(This article belongs to the Special Issue Diet and Metabolic Syndromes)
  |  
PDF [2636 KB, uploaded 16 May 2019]
  |     |  

Abstract

Long-chain polyunsaturated fatty acids, n-3 series (n-3 LC-PUFA), are known for their preventive effects against cardiovascular disease. In an unfavourable economic and environmental context of fish oil production, marine microalgae could be an alternative source of n-3 LC-PUFA and are of interest for human nutrition. The aim of this study was to evaluate the effects of P. tricornutum, a microalga rich in eicosapentaenoic acid and used as a food supplement, on the metabolic disorders associated with metabolic syndrome and obesity development. Three male Wistar rat groups (n = 6) were submitted for eight weeks to a standard diet or high-fat diet (HF) with 10% fructose in drinking water, supplemented or not with 12% of P. tricornutum (HF-Phaeo). Supplementation led to n-3 LC-PUFA enrichment of lipids in the liver, plasma and erythrocytes. Plasma transaminases showed no difference between the HF and HF-Phaeo groups. Body weight, fat mass, inflammatory markers and insulinemia decreased in HF-Phaeo rats versus the HF group. Plasma total cholesterol, triacylglycerols and leptine diminished in HF-Phaeo rats, while HDL-cholesterol increased. In conclusion, this study highlights the beneficial effects of P. tricornutum in reducing the metabolic disorders associated with metabolic syndrome. View Full-Text
Keywords: Phaeodactylum tricornutum; n-3 LC-PUFA; metabolic syndrome; dyslipidemia; inflammation Phaeodactylum tricornutum; n-3 LC-PUFA; metabolic syndrome; dyslipidemia; inflammation
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

Supplementary material

SciFeed

Share & Cite This Article

MDPI and ACS Style

Mayer, C.; Côme, M.; Ulmann, L.; Chini Zittelli, G.; Faraloni, C.; Nazih, H.; Ouguerram, K.; Chénais, B.; Mimouni, V. Preventive Effects of the Marine Microalga Phaeodactylum tricornutum, Used as a Food Supplement, on Risk Factors Associated with Metabolic Syndrome in Wistar Rats. Nutrients 2019, 11, 1069.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Nutrients EISSN 2072-6643 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top