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Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin

1
Instituto de Biología Molecular y Celular del Cáncer, CSIC and CIBERONC, 37007 Salamanca, Spain
2
Centro Regional de Investigaciones Biomédicas, Universidad de Castilla La Mancha, 02008 Albacete, Spain
3
Research and Development, Catalysis S.L., 28016 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(5), 1068; https://doi.org/10.3390/nu11051068
Received: 15 April 2019 / Revised: 3 May 2019 / Accepted: 13 May 2019 / Published: 14 May 2019
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Abstract

Nutritional supplements which include natural antitumoral compounds could represent safe and efficient additives for cancer patients. One such nutritional supplement, Ocoxin Oral solution (OOS), is a composite formulation that contains several antioxidants and exhibits antitumoral properties in several in vitro and in vivo tumor conditions. Here, we performed a functional genomic analysis to uncover the mechanism of the antitumoral action of OOS. Using in vivo models of acute myelogenous leukemia (AML, HEL cells, representative of a liquid tumor) and small-cell lung cancer (GLC-8, representative of a solid tumor), we showed that OOS treatment altered the transcriptome of xenografted tumors created by subcutaneously implanting these cells. Functional transcriptomic studies pointed to a cell cycle deregulation after OOS treatment. The main pathway responsible for this deregulation was the E2F–TFDP route, which was affected at different points. The alterations ultimately led to a decrease in pathway activation. Moreover, when OOS-deregulated genes in the AML context were analyzed in patient samples, a clear correlation with their levels and prognosis was observed. Together, these data led us to suggest that the antitumoral effect of OOS is due to blockade of cell cycle progression mainly caused by the action of OOS on the E2F–TFDP pathway. View Full-Text
Keywords: small-cell lung cancer; acute myeloid leukemia; antioxidants; cell cycle; p27; apoptosis small-cell lung cancer; acute myeloid leukemia; antioxidants; cell cycle; p27; apoptosis
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).

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Pérez-Peña, J.; Díaz-Rodríguez, E.; Sanz, E.; Pandiella, A. Central Role of Cell Cycle Regulation in the Antitumoral Action of Ocoxin. Nutrients 2019, 11, 1068.

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