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Bases for the Adequate Development of Nutritional Recommendations for Patients with Inflammatory Bowel Disease

1
Inflammatory Bowel Disease Unit, Gastroenterology Department, La Fe University and Polytechnic Hospital, 46026 Valencia, Spain
2
Inflammatory Bowel Disease Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), 46026 Valencia, Spain
3
Biomedical Research Network Center for Liver and Digestive Diseases (CIBEREHD), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
These authors contribute equally to this manuscript.
Nutrients 2019, 11(5), 1062; https://doi.org/10.3390/nu11051062
Received: 2 April 2019 / Revised: 7 May 2019 / Accepted: 10 May 2019 / Published: 12 May 2019
(This article belongs to the Special Issue Nutrition in Inflammatory Bowel Disease (IBD))
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Abstract

Inflammatory bowel disease (IBD) is a chronic and relapsing inflammatory condition of the gastrointestinal tract; it is a heterogeneous and multifactorial disorder resulting from a complex interplay between genetic variation, intestinal microbiota, the host immune system and environmental factors such as diet, drugs, breastfeeding and smoking. The interactions between dietary nutrients and intestinal immunity are complex. There is a compelling argument for environmental factors such as diet playing a role in the cause and course of IBD, given that three important factors in the pathogenesis of IBD can be modulated and controlled by diet: intestinal microbiota, the immune system and epithelial barrier function. The aim of this review is to summarize the epidemiological findings regarding diet and to focus on the effects that nutrients exert on the intestinal mucosa–microbiota–permeability interaction. The nature of these interactions in IBD is influenced by alterations in the nutritional metabolism of the gut microbiota and host cells that can influence the outcome of nutritional intervention. A better understanding of diet–host–microbiota interactions is essential for unravelling the complex molecular basis of epigenetic, genetic and environmental interactions underlying IBD pathogenesis as well as for offering new therapeutic approaches for the treatment of IBD. View Full-Text
Keywords: diet; inflammatory bowel disease; microbiota; intestinal barrier; nutrients; immunity diet; inflammatory bowel disease; microbiota; intestinal barrier; nutrients; immunity
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Sáez-González, E.; Mateos, B.; López-Muñoz, P.; Iborra, M.; Moret, I.; Nos, P.; Beltrán, B. Bases for the Adequate Development of Nutritional Recommendations for Patients with Inflammatory Bowel Disease. Nutrients 2019, 11, 1062.

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