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Nutrients 2019, 11(4), 772; https://doi.org/10.3390/nu11040772

Growth Benefits of Own Mother’s Milk in Preterm Infants Fed Daily Individualized Fortified Human Milk

1
Department of Neonatology, University of Liège, CHU and CHR Liège, 4000 Liège, Belgium
2
Human Milk Bank of CHR Liège, 4000 Liège, Belgium
3
Baxter Healthcare Corporation, Global Medical Affairs, 1420 Braine-l’Alleud, Belgium
*
Author to whom correspondence should be addressed.
Received: 15 March 2019 / Revised: 25 March 2019 / Accepted: 27 March 2019 / Published: 3 April 2019
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Abstract

The influence of types of human milk (HM)—raw own mother’s milk (OMM), pasteurized OMM, and donor milk (DM)—was evaluated for growth in premature infants fed exclusively HM with controlled nutritional intakes using daily individualized HM fortification (IHMF). Growth and nutritional intakes were prospectively collected in preterm infants (<32 weeks) fed IHMF and compared in infants fed predominantly (≥75%) OMM and DM. The influence of HM types (raw OMM, pasteurized OMM, and DM) on growth were also evaluated in the whole population. One-hundred and one preterm infants (birth weight 970 ± 255 g, gestational age 27.8 ± 1.9 weeks) were included. Energy (143 ± 8 vs. 141 ± 6 kcal/kg/day; p = 0.15) and protein intakes (4.17 ± 0.15 vs. 4.15 ± 0.14 g/kg/day; p = 0.51) were similar in both groups. Infants receiving predominantly OMM (n = 37), gained significantly more weight (19.8 ± 2.0 vs. 18.2 ± 2.2 g/kg/day; p = 0.002) and length (1.17 ± 0.26 vs. 0.99 ± 0.36 cm/week; p = 0.020) than those fed predominantly DM (n = 33). Stepwise multivariate analysis (n = 101) suggests that raw OMM was the major determinant of growth, contributing 22.7% of weight gain. Length gain was also related to OMM (raw + pasteurized) intakes, explaining 4.0% of length gain. In conclusion, at daily controlled similar protein and energy intakes, OMM had significant beneficial effects on weight and length versus DM in VLBW infants. This difference could be partially explained by the use of raw OMM. View Full-Text
Keywords: preterm; growth; human milk; donor milk; own mother’s milk; fortification preterm; growth; human milk; donor milk; own mother’s milk; fortification
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de Halleux, V.; Pieltain, C.; Senterre, T.; Studzinski, F.; Kessen, C.; Rigo, V.; Rigo, J. Growth Benefits of Own Mother’s Milk in Preterm Infants Fed Daily Individualized Fortified Human Milk. Nutrients 2019, 11, 772.

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