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Open AccessReview

The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders

1
Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Department of Neurosciences and Mental Health, 20122 Milan, Italy
2
Department of Clinical Sciences and Community Health, University of Milan, 20122 Milan, Italy
3
Neurologic Clinic, Fondazione IRCCS Istituto neurologico Carlo Besta, 20122 Milan, Italy
4
Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Pediatric Nephrology, Dialysis and Transplant Unit, 20122 Milan, Italy
5
Department of Pathophysiology and Transplantation, University of Milan, 20122 Milan, Italy
6
Fondazione IRCCS Ca’ Granda-Ospedale Maggiore Policlinico, Pediatric Intermediate Care Unit, 20122 Milan, Italy
*
Author to whom correspondence should be addressed.
Valentina Ciappolino and Alessandra Mazzocchi contributed equally to the review.
Nutrients 2019, 11(4), 769; https://doi.org/10.3390/nu11040769
Received: 22 February 2019 / Revised: 25 March 2019 / Accepted: 28 March 2019 / Published: 2 April 2019
(This article belongs to the Special Issue DHA and Neurocognitive Function)
Cognitive impairment is strongly associated with functional outcomes in psychiatric patients. Involvement of n-3 long chain polyunsaturated fatty acid (n-3 LC-PUFA), in particular docosahexaenoic acid (DHA), in brain functions is largely documented. DHA is incorporated into membrane phospholipids as structural component, especially in the central nervous system where it also has important functional effects. The aim of this review is to investigate the relationship between DHA and cognitive function in relation to mental disorders. Results from few randomized controlled trials (RCTs) on the effects of DHA (alone or in combination) in psychotic, mood and neurodevelopmental disorders, respectively, suggest that no conclusive remarks can be drawn. View Full-Text
Keywords: n-3 long chain polyunsaturated fatty acids; docosahexaenoic acid; psychiatric disorders; cognition; cognitive symptoms n-3 long chain polyunsaturated fatty acids; docosahexaenoic acid; psychiatric disorders; cognition; cognitive symptoms
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Ciappolino, V.; Mazzocchi, A.; Botturi, A.; Turolo, S.; Delvecchio, G.; Agostoni, C.; Brambilla, P. The Role of Docosahexaenoic Acid (DHA) on Cognitive Functions in Psychiatric Disorders. Nutrients 2019, 11, 769.

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