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Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review

1
Post-graduate Program in Health and Environment, University of Joinville Region, Rua Paulo Malschitzki, 10, Joinville, Santa Catarina, CEP 89.219-710, Brazil
2
Department of Health Sciences, University of Joinville Region, Rua Paulo Malschitzki, 10, Joinville, Santa Catarina, CEP 89.219-710, Brazil
3
Population Health Intervention Research Unit, School of Public Health, University of Alberta, 3-50 University Terrace, 8303–112 St, Edmonton, AB T6G 2T4, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(4), 750; https://doi.org/10.3390/nu11040750
Received: 28 January 2019 / Revised: 21 March 2019 / Accepted: 27 March 2019 / Published: 30 March 2019
(This article belongs to the Special Issue Energy Intake and Human Health)
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Abstract

This systematic review aims to evaluate the association of adiponectin (ADIPOQ) and leptin (LEP) gene variants with energy intake. Cross-sectional, cohort, and case–control studies that reported an association of leptin and/or adiponectin gene variants with energy intake were included in this review. Human studies without any age restrictions were considered eligible. Detailed individual search strategies were developed for each of the following bibliographic databases: Cochrane, Latin American and Caribbean Center on Health Sciences Information (LILACS), PubMed/MEDLINE, Scopus, and Web of Science. Risk of bias assessment was adapted from the Downs and Black scale and was used to evaluate the methodology of the included studies. Seven studies with a pooled population of 2343 subjects were included. The LEP and ADIPOQ gene variants studied were LEP-rs2167270 (k = 1), LEP-rs7799039 (k = 5), ADIPOQ-rs2241766 (k = 2), ADIPOQ-rs17300539 (k = 1), and ADIPOQ marker D3S1262 (k = 1). Two of the seven studies reviewed demonstrated a positive association between the LEP-rs7799039 polymorphism and energy intake. Two other studies—one involving a marker of the ADIPOQ gene and one examining the ADIPOQ-rs17300539 polymorphism—also reported associations with energy intake. More research is needed to further elucidate the contributions of genetic variants to energy metabolism. View Full-Text
Keywords: ADIPOQ; LEP; energy intake; adipocytokines; leptin ADIPOQ; LEP; energy intake; adipocytokines; leptin
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Kroll, C.; Mastroeni, S.S.; Veugelers, P.J.; Mastroeni, M.F. Associations of ADIPOQ and LEP Gene Variants with Energy Intake: A Systematic Review. Nutrients 2019, 11, 750.

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