U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults
Abstract
:1. Introduction
2. Materials and Methods
2.1. Participants
2.2. Circulating Leptin Concentration
2.3. Assessment of Cognitive Performance
2.4. Assessments of Potential Confounders
2.5. Statistical Analysis
2.6. Ethics
3. Results
4. Discussion
5. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Quintiles of Circulating Leptin Concentration, ng/mL | Overall p-Value * | ||||||
---|---|---|---|---|---|---|---|
Whole Cohort (n = 1061) | Q1 (n = 212) ≤2.64 | Q2 (n = 206) 2.65–5.1 | Q3 (n = 222) 5.2–8.6 | Q4 (n = 212) 8.7–17.96 | Q5 (n = 209) ≥18 | ||
Demographical measures | |||||||
Age, years | 70.6 ± 6.4 | 71.5 ± 6.5 | 69.9 ± 6.2 | 70.7 ± 6.3 | 70.6 ± 6.6 | 69.9 ± 6.4 | 0.067 |
Female gender, n (%) | 441 (41.6) | 32 (15.1) | 35 (17.0) | 77 (34.7) | 122 (57.5) | 175 (83.7) | <0.001 b,c,d,e,f,g,h,i,j |
Regular smoking, n (%) | 342 (32.2) | 98 (46.2) | 90 (43.7) | 91 (41.0) | 44 (20.8) | 19 (9.1) | <0.001 c,d,f,g,h,i,j |
Regular alcohol consumption †, n (%) | 16 (1.5) | 6 (2.8) | 5 (2.4) | 2 (0.9) | 0 (0.0) | 3 (1.4) | 0.112 |
High education level ‡, n (%) | 447 (42.1) | 90 (42.5) | 101 (49.0) | 102 (45.9) | 83 (39.2) | 71 (34.0) | 0.019 f,g,i |
Clinical measures | |||||||
Body mass index, kg/m2 | 24.8 ± 4.6 | 21.2 ± 2.9 | 23.5 ± 2.7 | 24.1 ± 2.9 | 25.3 ± 3.2 | 29.8 ± 5.7 | <0.001 a,b,c,d,e,f,g,h,i,j |
Mean arterial pressure, mmHg | 98.3 ± 11.0 | 98.5 ± 11.2 | 98.2 ± 10.8 | 98.6 ± 10.8 | 98.5 ± 11.1 | 97.5 ± 11.1 | 0.810 |
Memory complaint, n (%) | 292 (48.6) | 69 (50.4) | 53 (49.5) | 59 (49.2) | 60 (50.8) | 51 (42.9) | 0.730 |
Anxiodepressive disorders, n (%) | 282 (26.6) | 35 (16.5) | 39 (18.9) | 51 (23.0) | 68 (32.1) | 89 (42.6) | <0.001 c,d,f,g,h,i,j |
Blood measures | |||||||
Leptin, ng/mL | 12.1 ± 15.5 | 1.5 ± 0.6 | 3.7 ± 0.7 | 6.7 ± 1.0 | 12.6 ± 2.66 | 36.4 ± 20.3 | - |
Glycosylated hemoglobin, % | 6.4 ± 1.1 | 6.2 ± 1.1 | 6.3 ± 1.1 | 6.4 ± 1.0 | 6.5 ± 1.1 | 6.5 ± 1.0 | 0.003 b,c,d,f |
LDL cholesterol concentration, mmol/L | 3.0 ± 0.9 | 3.1 ± 0.9 | 2.9 ± 0.8 | 3.0 ± 1.0 | 3.0 ± 0.9 | 3.0 ± 0.8 | 0.249 |
25-hydroxyvitamin D, µg/L | 22.3 ± 11.2 | 30.1 ± 10.3 | 27.8 ± 11.1 | 25.1 ± 10.4 | 23.1 ± 11.5 | 20.2 ± 9.8 | <0.001 a,b,c,d,e,f,g,h,i,j |
Estimated glomerular filtration rate, mL/min | 69.2 ± 20.3 | 73.5 ± 17.4 | 72.4 ± 19.1 | 69.2 ± 20.4 | 68.3 ± 20.9 | 62.5 ± 21.7 | <0.001 b,c,d,f,g,i,j |
Circulating Leptin Concentration, ng/mL | |||||||||
---|---|---|---|---|---|---|---|---|---|
Q1 (Lowest) | Q2 | Q3 | Q4 | Q5 (Highest) | |||||
β (95% CI) | p-Value | β (95% CI) | p-Value | β | β (95% CI) | p-Value | β (95% CI) | p-Value | |
AMT score, /10 | |||||||||
Unadjusted model | −0.10 (−0.40;0.19) | 0.489 | 0.24 (−0.02;0.51) | 0.071 | ref | −0.37 (−0.68;−0.06) | 0.021 | −0.71 (−1.05;−0.38) | <0.001 |
Fully adjusted model * | −0.53 (−0.98;−0.09) | 0.018 | −0.08 (−0.45;0.30) | 0.697 | ref | −0.08 (−0.52;0.36) | 0.724 | −0.60 (−1.15;−0.04) | 0.036 |
Anterograde episodic memory subscore, /1 | |||||||||
Unadjusted model | −0.03 (−0.12;0.06) | 0.538 | 0.04 (−0.05;0.13) | 0.402 | ref | −0.06 (−0.16;0.03) | 0.192 | −0.17 (−0.26;−0.08) | <0.001 |
Fully adjusted model * | −0.06 (−0.21;0.09) | 0.409 | −0.00 (−0.13;0.13) | 0.981 | ref | −0.28 (−0.16;0.10) | 0.677 | −0.19 (−0.35;−0.03) | 0.020 |
Retrograde episodic memory subscore, /2 | |||||||||
Unadjusted model | −0.01 (−0.09;0.07) | 0.770 | 0.06 (−0.01;0.13) | 0.094 | ref | −0.11 (−0.20;−0.02) | 0.018 | −0.19 (−0.28;−0.09) | <0.001 |
Fully adjusted model * | −0.11 (−0.25;0.02) | 0.101 | −0.01 (−0.12;0.10) | 0.824 | ref | −0.06 (−0.20;0.08) | 0.401 | −0.18 (−0.35;−0.09) | 0.039 |
Semantic memory subscore, /2 | |||||||||
Unadjusted model | −0.008 (−0.09;0.08) | 0.852 | 0.04 (−0.05;0.12) | 0.404 | ref | −0.12 (−0.21;−0.03) | 0.012 | −0.12 (−0.22;−0.03) | 0.012 |
Fully adjusted model * | −0.05 (−0.18;0.09) | 0.504 | −0.03 (−0.16;0.10) | 0.629 | ref | −0.05 (−0.19;0.09) | 0.450 | −0.16 (−0.34;0.01) | 0.068 |
Working memory subscore, /1 | |||||||||
Unadjusted model | −0.05 (−0.12;0.02) | 0.127 | 0.03 (−0.03;0.09) | 0.357 | ref | −0.10 (−0.17;−0.03) | 0.006 | −0.10 (−0.17;−0.03) | 0.007 |
Fully adjusted model * | −0.10 (−0.21;0.01) | 0.074 | −0.04 (−0.13;0.06) | 0.476 | ref | −0.06 (−0.16;0.05) | 0.279 | −0.07 (−0.20;0.06) | 0.281 |
Orientation in space subscore, /1 | |||||||||
Unadjusted model | −0.006 (−0.04;0.02) | 0.703 | 0.01 (−0.01;0.04) | 0.297 | ref | 0.01 (−0.02;0.03) | 0.518 | 0.00 (−0.02;0.03) | 0.807 |
Fully adjusted model* | −0.05 (−0.11;−0.00) | 0.048 | −0.00 (−0.05;0.04) | 0.882 | ref | 0.04 (0.00;0.08) | 0.043 | 0.03 (−0.03;0.09) | 0.287 |
Orientation in time subscore, /2 | |||||||||
Unadjusted model | 0.003 (−0.06;0.07) | 0.922 | 0.06 (0.01;0.12) | 0.031 | ref | −0.00 (−0.07;0.07) | 0.966 | −0.11 (−0.19;−0.04) | 0.004 |
Fully adjusted model * | −0.09 (−0.20;0.02) | 0.116 | 0.02 (−0.07;0.11) | 0.700 | ref | 0.07 (−0.03;0.17) | 0.186 | −0.01 (−0.14;0.13) | 0.922 |
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Annweiler, C.; Duval, G.T.; Cheng, C.-Y.; Wong, T.-Y.; Lamoureux, E.L.; Milea, D.; Sabanayagam, C. U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults. Nutrients 2019, 11, 660. https://doi.org/10.3390/nu11030660
Annweiler C, Duval GT, Cheng C-Y, Wong T-Y, Lamoureux EL, Milea D, Sabanayagam C. U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults. Nutrients. 2019; 11(3):660. https://doi.org/10.3390/nu11030660
Chicago/Turabian StyleAnnweiler, Cedric, Guillaume T. Duval, Ching-Yu Cheng, Tien-Yin Wong, Ecosse L. Lamoureux, Dan Milea, and Charumathi Sabanayagam. 2019. "U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults" Nutrients 11, no. 3: 660. https://doi.org/10.3390/nu11030660
APA StyleAnnweiler, C., Duval, G. T., Cheng, C.-Y., Wong, T.-Y., Lamoureux, E. L., Milea, D., & Sabanayagam, C. (2019). U-Shaped Relationship between Serum Leptin Concentration and Cognitive Performance in Older Asian Adults. Nutrients, 11(3), 660. https://doi.org/10.3390/nu11030660