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Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity

by Starin McKeen 1,2,3, Wayne Young 1,2,3, Jane Mullaney 1,2,3, Karl Fraser 1,2,3, Warren C. McNabb 2,3 and Nicole C. Roy 1,2,3,*
AgResearch, Food Nutrition & Health, Grasslands Research Centre, Private Bag 11008, Palmerston north 4442, New Zealand
Riddet Institute, Massey University, Private Bag 11222, Palmerston North 4442, New Zealand
High-Value Nutrition National Science Challenge, Auckland, New Zealand
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 364;
Received: 7 January 2019 / Revised: 1 February 2019 / Accepted: 6 February 2019 / Published: 9 February 2019
(This article belongs to the Special Issue Diet and Immune Function)
Complementary feeding transitions infants from a milk-based diet to solid foods, providing essential nutrients to the infant and the developing gut microbiome while influencing immune development. Some of the earliest microbial colonisers readily ferment select oligosaccharides, influencing the ongoing establishment of the microbiome. Non-digestible oligosaccharides in prebiotic-supplemented formula and human milk oligosaccharides promote commensal immune-modulating bacteria such as Bifidobacterium, which decrease in abundance during weaning. Incorporating complex, bifidogenic, non-digestible carbohydrates during the transition to solid foods may present an opportunity to feed commensal bacteria and promote balanced concentrations of beneficial short chain fatty acid concentrations and vitamins that support gut barrier maturation and immunity throughout the complementary feeding window. View Full-Text
Keywords: weaning; oligosaccharides; non-digestible carbohydrates; metabolites; gut barrier; tolerance weaning; oligosaccharides; non-digestible carbohydrates; metabolites; gut barrier; tolerance
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McKeen, S.; Young, W.; Mullaney, J.; Fraser, K.; McNabb, W.C.; Roy, N.C. Infant Complementary Feeding of Prebiotics for the Microbiome and Immunity. Nutrients 2019, 11, 364.

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