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Open AccessReview

Experimental Outcomes of the Mediterranean Diet: Lessons Learned from the Predimed Randomized Controlled Trial

1
Research Institute of Biomedical and Health Sciences, University of Las Palmas de Gran Canaria, 35016 Las Palmas de Gran Canaria, Spain
2
Department of Nutrition and Dietetics, Institute of Health Sciences, Marmara University, 34854 Istanbul, Turkey
3
Department of Clinical and Community Health (DISCCO), Universita’ degli Studi di Milano, 20122 Milan, Italy
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Complejo Hospitalario Universitario Insular-Materno Infantil (CHUIMI), Canarian Health Services, 35016 Las Palmas de Gran Canaria, Spain
5
Consorcio CIBER, M.P. Fisiopatologia de la Obesidad y Nutricion (CIBERObn), Instituto de Salud Carlos III (ISCIII), 28029 Madrid, Spain
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2991; https://doi.org/10.3390/nu11122991
Received: 14 October 2019 / Revised: 7 November 2019 / Accepted: 15 November 2019 / Published: 6 December 2019
(This article belongs to the Special Issue Selected Papers from NUTRIMAD 2018)
The Mediterranean Diet (MD) is, culturally and historically, the nutritional pattern shared by people living in the olive-tree growing areas of the Mediterranean basin. It is of great importance for its potential preventive effect against cardiovascular diseases (CVDs). The PREvención con DIeta MEDiterránea (PREDIMED) study, a Spanish multicentre randomised controlled trial (RCT), was designed to assess the long-term effects of the MD, without any energy restriction, on the incidence of CVD in individuals at high cardiovascular (CV) risk. Since its inception, it gave a great contribution to the available literature on the issue. It is well known that, in the field of the health sciences, RCTs provide the best scientific evidence. Thus, the aim of the present review is to analyse the results of the RCTs performed within the frame of the PREDIMED study. Our findings showed that MD has beneficial effects in the primary prevention of CVDs, diabetes and in the management of metabolic syndrome. View Full-Text
Keywords: PREDIMED; Mediterranean diet; dietary intervention; randomized controlled trials; cardiovascular disease; type-2 diabetes mellitus; metabolic syndrome PREDIMED; Mediterranean diet; dietary intervention; randomized controlled trials; cardiovascular disease; type-2 diabetes mellitus; metabolic syndrome
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Kargin, D.; Tomaino, L.; Serra-Majem, L. Experimental Outcomes of the Mediterranean Diet: Lessons Learned from the Predimed Randomized Controlled Trial. Nutrients 2019, 11, 2991.

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