Next Article in Journal
Dietary Curcumin Supplementation Increases Antioxidant Capacity, Upregulates Nrf2 and Hmox1 Levels in the Liver of Piglet Model with Intrauterine Growth Retardation
Next Article in Special Issue
A Narrative Review on the Potential of Red Beetroot as an Adjuvant Strategy to Counter Fatigue in Children with Cancer
Previous Article in Journal
Subphenotypes in Patients with Septic Shock Receiving Vitamin C, Hydrocortisone, and Thiamine: A Retrospective Cohort Analysis
Previous Article in Special Issue
Poor Dietary Polyphenol Intake in Childhood Cancer Patients
Open AccessArticle

Dietary Intakes Are Associated with HDL-Cholesterol in Survivors of Childhood Acute Lymphoblastic Leukaemia

1
Research Centre, Sainte-Justine University Health Center, Departments of Nutrition, Université de Montréal, Montreal, QC H3T 1C5, Canada
2
Institute of Nutrition and Functional Foods, Laval University, Quebec City, QC G1V 0A6, Canada
3
Research Centre, Sainte-Justine University Health Center, Departments of Pediatrics, Université de Montréal, Montreal, QC H3T 1C5, Canada
4
Research Centre, Sainte-Justine University Health Center, Departments of Kinesiology, Université de Montréal, Montreal, QC H3T 1C5, Canada
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2977; https://doi.org/10.3390/nu11122977
Received: 21 October 2019 / Revised: 28 November 2019 / Accepted: 4 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Important Aspects of Nutrition in Children with Cancer)
Survivors of childhood acute lymphoblastic leukemia (cALL) are at high risk of developing dyslipidemia, including low HDL-cholesterol (HDL-C). This study aimed to examine the associations between food/nutrient intake and the levels of HDL-C in a cohort of children and young adult survivors of cALL. Eligible participants (n = 241) were survivors of cALL (49.4% boys; median age: 21.7 years old) recruited as part of the PETALE study. Nutritional data were collected using a validated food frequency questionnaire. Fasting blood was used to determine participants’ lipid profile. Multivariable logistic regression models were fitted to evaluate the associations between intakes of macro- and micronutrients and food groups and plasma lipids. We found that 41.3% of cALL survivors had at least one abnormal lipid value. Specifically, 12.2% had high triglycerides, 17.4% high LDL-cholesterol, and 23.1% low HDL-C. Low HDL-C was inversely associated with high intake (third vs. first tertile) of several nutrients: proteins (OR: 0.27, 95% CI: 0.08–0.92), zinc (OR: 0.26, 95% CI: 0.08–0.84), copper (OR: 0.34, 95% CI: 0.12–0.99), selenium (OR: 0.17, 95% CI: 0.05–0.59), niacin (OR: 0.25, 95% CI: 0.08–0.84), riboflavin (OR: 0.31, 95% CI: 0.12–0.76) and vitamin B12 (OR: 0.35, 95% CI: 0.13–0.90). High meat consumption was also inversely associated (OR: 0.28, 95% CI: 0.09–0.83) with low HDL-C while fast food was positively associated (OR: 2.41, 95% CI: 1.03–5.63) with low HDL-C. The role of nutrition in the development of dyslipidemia after cancer treatment needs further investigation. View Full-Text
Keywords: childhood leukemia survivor; HDL-cholesterol; nutrition; adolescent; young adults childhood leukemia survivor; HDL-cholesterol; nutrition; adolescent; young adults
Show Figures

Figure 1

MDPI and ACS Style

Morel, S.; Amre, D.; Teasdale, E.; Caru, M.; Laverdière, C.; Krajinovic, M.; Sinnett, D.; Curnier, D.; Levy, E.; Marcil, V. Dietary Intakes Are Associated with HDL-Cholesterol in Survivors of Childhood Acute Lymphoblastic Leukaemia. Nutrients 2019, 11, 2977.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Search more from Scilit
 
Search
Back to TopTop