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Article

Giardia intestinalis and Fructose Malabsorption: A Frequent Association

1
Area of Parasitology, Department of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46010 Valencia, Spain
2
Joint Research Unit on Endocrinology, Nutrition and Clinical Dietetics, University of Valencia-Health Research Institute La Fe, 46026 Valencia, Spain
3
University Clinic of Nutrition, Physical Activity and Physiotherapy (CUNAFF), Lluís Alcanyís Foundation-University of Valencia, 46020 Valencia, Spain
4
Area of Nutrition and Bromatology, University of Valencia, 46010 Valencia, Spain
5
Department of Gastroenterology, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
6
Food & Health Lab, Institute of Materials Science, University of Valencia, 46980 Paterna, Spain
7
Biochemistry and Molecular Parasitology Group, Department of Parasitology, Institute of Biotechnology, University of Granada, 18003 Granada, Spain
8
Department of Endocrinology and Nutrition, University and Polytechnic Hospital La Fe, 46026 Valencia, Spain
9
Department of Medicine, University of Valencia, 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
These authors contributed equally to this paper.
Nutrients 2019, 11(12), 2973; https://doi.org/10.3390/nu11122973
Received: 30 October 2019 / Revised: 29 November 2019 / Accepted: 3 December 2019 / Published: 5 December 2019
(This article belongs to the Special Issue Fructose and Glucose Intake and Human Health)
Nowadays, scientific studies are emerging on the possible etiological role of intestinal parasites in functional digestive disorders. Our study was carried out with healthy individuals (control group; n = 82) and symptomatic patients with lactose or fructose malabsorption, including positive (malabsorbers; n = 213) and negative (absorbers; n = 56) breath test, being analyzed for the presence of intestinal parasites. A high parasitic prevalence was observed in malabsorbers (41.8%), exclusively due to single-cell eukaryotes but not helminths. Giardia intestinalis was the predominant parasite in cases of abnormal absorption (26.5%), significantly associated with fructose malabsorption and doubling the probability of developing this pathology. Within controls, Blastocystis sp. (13.4%) was almost the only parasite, being the second among patients (12.6%), and Cryptosporidium parvum, the last species of clinical relevance, was detected exclusively in two malabsorbers (0.9%). The consumption of ecological food and professions with direct contact with humans arose as risk factors of parasitism. A diagnosis of carbohydrate malabsorption in adulthood is the starting point, making the search for the primary cause necessary. Accurate parasitological diagnosis should be considered another tool in the clinical routine for patients with recurrent symptoms, since their condition may be reversible with adequate therapeutic intervention. View Full-Text
Keywords: parasites; Giardia intestinalis; Blastocystis sp.; carbohydrates; malabsorption; fructose; risk factors parasites; Giardia intestinalis; Blastocystis sp.; carbohydrates; malabsorption; fructose; risk factors
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MDPI and ACS Style

Trelis, M.; Taroncher-Ferrer, S.; Gozalbo, M.; Ortiz, V.; Soriano, J.M.; Osuna, A.; Merino-Torres, J.F. Giardia intestinalis and Fructose Malabsorption: A Frequent Association. Nutrients 2019, 11, 2973. https://doi.org/10.3390/nu11122973

AMA Style

Trelis M, Taroncher-Ferrer S, Gozalbo M, Ortiz V, Soriano JM, Osuna A, Merino-Torres JF. Giardia intestinalis and Fructose Malabsorption: A Frequent Association. Nutrients. 2019; 11(12):2973. https://doi.org/10.3390/nu11122973

Chicago/Turabian Style

Trelis, María, Silvia Taroncher-Ferrer, Mónica Gozalbo, Vicente Ortiz, José M. Soriano, Antonio Osuna, and Juan F. Merino-Torres 2019. "Giardia intestinalis and Fructose Malabsorption: A Frequent Association" Nutrients 11, no. 12: 2973. https://doi.org/10.3390/nu11122973

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