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Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered

Cattedra di Gastroenterologia, Dipartimento di Medicina Interna, Università degli Studi di Genova, 16132 Genova, Italy
Programma Dipartimentale Diagnosi e Terapia delle Malattie Emergenti dell’Apparato Digerente, IRCCS Ospedale Policlinico San Martino, 16132 Genova, Italy
Divisione di Medicine Interna ed Epatologia, Humanitas Clinical and Research Center-IRCCS, 20089 Rozzano, Italy
Dipartimento di Scienze Biomediche, Humanitas University, 20090 Pieve Emanuele, Italy
Area Medicina Interna, Gastroenterologia e Medicina Interna, Fondazione Policlinico Gemelli IRCCS, Università Cattolica del Sacro Cuore, 20123 Roma, Italy
Gastroenterology Unit, Department of Internal Medicine, University of Genoa, Viale Benedetto XV, no.6, 16132 Genoa, Italy
Author to whom correspondence should be addressed.
Maria Corina Plaz Torres and Alessio Aghemo share first authorship of the manuscript.
Luca Miele and Edoardo G. Giannini share last authorship of the manuscript.
Nutrients 2019, 11(12), 2971;
Received: 11 November 2019 / Revised: 28 November 2019 / Accepted: 30 November 2019 / Published: 5 December 2019
Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome and is expected to become the leading cause of end-stage liver disease worldwide over the next few decades. In fact, NAFLD encompasses different clinical scenarios, from the simple accumulation of fat (steatosis) to steatohepatitis (NASH), NASH-cirrhosis, and cirrhosis complications. In this context, it is fundamental to pursue strategies aimed at both preventing the disease and reducing the progression of liver fibrosis once liver damage is already initiated. As of today, no pharmacological treatment has been approved for NAFLD/NASH, and the only recommended treatment of proven efficacy are life-style modifications, including diet and physical exercise pointing at weight loss of 5%–7%. Different dietetic approaches have been proposed in this setting, and in this review, we will discuss the evidence regarding the efficacy of the Mediterranean Diet as a treatment for NAFLD. In particular, we will report the effects on liver-related outcomes. View Full-Text
Keywords: nonalcoholic steatohepatitis; chronic liver disease; lifestyle intervention; diet; outcome nonalcoholic steatohepatitis; chronic liver disease; lifestyle intervention; diet; outcome
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Plaz Torres, M.C.; Aghemo, A.; Lleo, A.; Bodini, G.; Furnari, M.; Marabotto, E.; Miele, L.; Giannini, E.G. Mediterranean Diet and NAFLD: What We Know and Questions That Still Need to Be Answered. Nutrients 2019, 11, 2971.

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