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Open AccessArticle

Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring

Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, Brazil
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2902;
Received: 11 November 2019 / Revised: 11 November 2019 / Accepted: 19 November 2019 / Published: 1 December 2019
(This article belongs to the Special Issue Respiratory Disease and Nutrition)
: It was previously demonstrated that non-allergen-sensitized rodents born to mothers exposed to a high-fat diet (HFD) spontaneously develop lower respiratory compliance and higher respiratory resistance. In the present study, we sought to determine if mice born to mothers consuming HFD would exhibit changes in inflammatory response and lung remodeling when subjected to ovalbumin (OVA) sensitization/challenge in adult life. Mice born to dams consuming either HFD or standard chow had increased bronchoalveolar lavage (BAL) levels of IL-1β, IL-4, IL-5, IL-10, IL-13, TNF-α and TGF-β1 after challenge with OVA. IL-4, IL-13, TNF-α and TGF-β1 levels were further increased in the offspring of HFD-fed mothers. Mice born to obese dams also had exacerbated values of leukocyte infiltration in lung parenchyma, eosinophil and neutrophil counts in BAL, mucus overproduction and collagen deposition. The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. Altogether, the present data support the unprecedented notion that the progeny of obese mice display exacerbated responses to sensitization/challenge with OVA, leading to the intensification of the morphological changes of lung remodeling. Such changes are likely to result from long-lasting changes in miR-155 and miR-133b expression.
Keywords: obesity; pregnancy; allergic airway disease; offspring; high fat diet obesity; pregnancy; allergic airway disease; offspring; high fat diet
MDPI and ACS Style

e-Lacerda, R.R.; Teixeira, C.J.; Bordin, S.; Antunes, E.; Anhê, G.F. Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring. Nutrients 2019, 11, 2902.

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