Next Article in Journal
Combined Treatment with Omega-3 Fatty Acid and Cholecalciferol Increases 1,25-Dihydroxyvitamin D Levels by Modulating Dysregulation of Vitamin D Metabolism in 5/6 Nephrectomy Rats
Previous Article in Journal
The Impact of Herbs and Spices on Increasing the Appreciation and Intake of Low-Salt Legume-Based Meals
Previous Article in Special Issue
Optimizing Nutrition Assessment to Create Better Outcomes in Lung Transplant Recipients: A Review of Current Practices
Open AccessArticle

Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring

1
Department of Pharmacology, Faculty of Medical Sciences, State University of Campinas, 13083-881 Campinas, SP, Brazil
2
Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of Sao Paulo, 05508-900 Sao Paulo, SP, Brazil
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2902; https://doi.org/10.3390/nu11122902
Received: 11 November 2019 / Revised: 11 November 2019 / Accepted: 19 November 2019 / Published: 1 December 2019
(This article belongs to the Special Issue Respiratory Disease and Nutrition)
: It was previously demonstrated that non-allergen-sensitized rodents born to mothers exposed to a high-fat diet (HFD) spontaneously develop lower respiratory compliance and higher respiratory resistance. In the present study, we sought to determine if mice born to mothers consuming HFD would exhibit changes in inflammatory response and lung remodeling when subjected to ovalbumin (OVA) sensitization/challenge in adult life. Mice born to dams consuming either HFD or standard chow had increased bronchoalveolar lavage (BAL) levels of IL-1β, IL-4, IL-5, IL-10, IL-13, TNF-α and TGF-β1 after challenge with OVA. IL-4, IL-13, TNF-α and TGF-β1 levels were further increased in the offspring of HFD-fed mothers. Mice born to obese dams also had exacerbated values of leukocyte infiltration in lung parenchyma, eosinophil and neutrophil counts in BAL, mucus overproduction and collagen deposition. The programming induced by maternal obesity was accompanied by increased expression of miR-155 in peripheral-blood mononuclear cells and reduced miR-133b in trachea and lung tissue in adult life. Altogether, the present data support the unprecedented notion that the progeny of obese mice display exacerbated responses to sensitization/challenge with OVA, leading to the intensification of the morphological changes of lung remodeling. Such changes are likely to result from long-lasting changes in miR-155 and miR-133b expression.
Keywords: obesity; pregnancy; allergic airway disease; offspring; high fat diet obesity; pregnancy; allergic airway disease; offspring; high fat diet
MDPI and ACS Style

e-Lacerda, R.R.; Teixeira, C.J.; Bordin, S.; Antunes, E.; Anhê, G.F. Maternal Obesity in Mice Exacerbates the Allergic Inflammatory Response in the Airways of Male Offspring. Nutrients 2019, 11, 2902.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop