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Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial

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Department of Medicine, Division of Geriatric Medicine, Sir Mortimer B. Davis-Jewish General Hospital and Lady Davis Institute for Medical Research, McGill University, Montreal, QC H3T 1E2, Canada
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Geriatric Medicine, Faculty of Medicine, McGill University, Montreal, QC H3T 1E2, Canada
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Centre of Excellence on Longevity of McGill Integrated University Health Network, Montreal, QC H3T 1E2, Canada
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Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore 308232, Singapore
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Nutrition & Regulatory Affairs, Yoplait SAS, 92641 Boulogne-Billancourt, France
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Regulatory Affairs, Les Maîtres Laitiers du Cotentin, 50260 Sottevast, France
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The Bell Institute of Health and Nutrition, General Mills Inc., Minneapolis, MN 55427, USA
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Department of Neurology, Geneva University Hospital and University of Geneva, 1205 Genève, Switzerland
*
Author to whom correspondence should be addressed.
Running title: Non-bone effects of vitamin D and calcium fortified yogurt.
Nutrients 2019, 11(12), 2880; https://doi.org/10.3390/nu11122880
Received: 23 October 2019 / Revised: 14 November 2019 / Accepted: 18 November 2019 / Published: 26 November 2019
Background: Vitamin D3 fortified food may improve serum vitamin D level, suggesting that the prevention of adverse consequences of hypovitaminosis D is possible with food fortification. The aim of this randomized controlled trial (RCT) was to examine the effects of vitamin D and calcium fortified yogurt on spatiotemporal gait parameters, cognitive performance, handgrip strength, and serum 25OHD levels in healthy older females. Methods: Forty older community-dwelling females were recruited in a single-blind, randomized, controlled, superiority clinical trial in two parallel groups (20 participants in the intervention group and 20 in the control group) with intent-to-treat. The intervention group took fortified yogurts daily (i.e., 400 UI of vitamin D3 and 800 mg calcium) for 3 months. The non-fortified yogurts contained similar proteins, carbohydrates and lipids, as well as a lower dose of calcium (300 mg) and no vitamin D3 supplementation. Spatiotemporal gait parameters (mean value and coefficient of variation) were assessed using a computerized walkway. Handgrip strength was measured with hydraulic dynamometers. Cognitive performances, including global cognitive functioning assessed with the Mini Mental Status Examination (MMSE) were recorded. All the outcomes were assessed at baseline and at the end of follow-up. The primary outcome was the coefficient of variation of stride time. Results: The intervention group maintained its global cognitive performance and serum 25OHD concentrations, whereas these outcomes decreased (i.e., worst performance) in the control group. The changes in the MMSE score (p = 0.022) and serum 25OHD concentrations were different (p ≤ 0.001) with better values reported in the intervention group compared to the control group. There was no significant change in gait parameters (p ≥ 0.518) and handgrip strength (p ≥ 0.600). Conclusions: Fortified yogurts with vitamin D (i.e., 200 IU) and calcium (i.e., 400 mg) twice a day maintained global cognitive performance and vitamin D status in older females, but not gait performances, signifying that they mainly prevent hypovitaminosis D-related extra-skeletal disorders. View Full-Text
Keywords: older adults; randomized controlled trial; hypovitaminosis D; gait; cognition older adults; randomized controlled trial; hypovitaminosis D; gait; cognition
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Beauchet, O.; Launay, C.P.; Galery, K.; Vilcocq, C.; Dontot-Payen, F.; Rousseau, B.; Benoit, V.; Allali, G. Effects of Vitamin D and Calcium Fortified Yogurts on Gait, Cognitive Performances, and Serum 25-Hydroxyvitamin D Concentrations in Older Community-Dwelling Females: Results from the GAit, MEmory, Dietary and Vitamin D (GAME-D2) Randomized Controlled Trial. Nutrients 2019, 11, 2880.

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