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Vitamin D Deficiency and Sarcopenia in Older Persons

Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy
Author to whom correspondence should be addressed.
Nutrients 2019, 11(12), 2861;
Received: 5 November 2019 / Accepted: 18 November 2019 / Published: 21 November 2019
(This article belongs to the Special Issue Sarcopenia and Nutritional Status)
Vitamin D deficiency is a common health problem worldwide, in particular among older people. Vitamin D regulates and modulates the physiology and function of multiple human systems, including the skeletal muscle. The effect of vitamin D on the muscle has been widely investigated, suggesting that this hormone can stimulate the proliferation and differentiation of skeletal muscle fibers, maintaining and improving muscle strength and physical performance. Older persons have a higher prevalence of low Vitamin D levels as a consequence of low dietary intake and reduced ultraviolet irradiation of the skin. Therefore, older people with vitamin D deficiency might be at risk of sarcopenia, a geriatric syndrome characterized by the progressive loss of skeletal muscle mass and strength often complicated by adverse events, such as falls, disability hospitalization and death. Several randomized clinical trials have been conducted to investigate the effect of oral vitamin D supplementation in older patients to prevent or treat sarcopenia, but results are still controversial. In this narrative review we summarize the biological, clinical and epidemiological evidence supporting the hypothesis of a causal association between Vitamin D deficiency and an increased risk of sarcopenia in older people. View Full-Text
Keywords: Vitamin D; aging; physical frailty; malnutrition; sarcopenia; nutritional intervention Vitamin D; aging; physical frailty; malnutrition; sarcopenia; nutritional intervention
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MDPI and ACS Style

Remelli, F.; Vitali, A.; Zurlo, A.; Volpato, S. Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients 2019, 11, 2861.

AMA Style

Remelli F, Vitali A, Zurlo A, Volpato S. Vitamin D Deficiency and Sarcopenia in Older Persons. Nutrients. 2019; 11(12):2861.

Chicago/Turabian Style

Remelli, Francesca, Aurora Vitali, Amedeo Zurlo, and Stefano Volpato. 2019. "Vitamin D Deficiency and Sarcopenia in Older Persons" Nutrients 11, no. 12: 2861.

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